{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:33:08Z","timestamp":1789475588299,"version":"build-2803163510"},"reference-count":41,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Congenital syphilis is still a cause of perinatal morbidity and mortality. Untreated maternal infection leads to adverse pregnancy outcomes, including early fetal loss, stillbirth, prematurity, low birth weight, neonatal and infant death, and congenital disease among newborns. Clinical manifestations of congenital syphilis are influenced by gestational age, stage of maternal syphilis, maternal treatment, and immunological response of the fetus. It has been traditionally classified in early congenital syphilis and late congenital syphilis. Diagnosis of maternal infection is based on clinical findings, serological tests, and direct identification of treponemes in clinical specimens. Adequate treatment of maternal infection is effective for preventing maternal transmission to the fetus and for treating fetal infection. Prenatal diagnosis of congenital syphilis includes noninvasive and invasive diagnosis. Serological screening during pregnancy and during preconception period should be performed to reduce the incidence of congenital syphilis.<\/jats:p>","DOI":"10.1155\/2012\/430585","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T06:16:40Z","timestamp":1341469000000},"page":"1-5","source":"Crossref","is-referenced-by-count":108,"title":["Syphilis Infection during Pregnancy: Fetal Risks and Clinical Management"],"prefix":"10.1155","volume":"2012","author":[{"given":"Marco","family":"De Santis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universit\u00e0 Cattolica del Sacro Cuore, Policlinico \u201cA. Gemelli\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universit\u00e0 Cattolica del Sacro Cuore, Policlinico \u201cA. Gemelli\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Mappa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universit\u00e0 Cattolica del Sacro Cuore, Policlinico \u201cA. Gemelli\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terryann","family":"Spagnuolo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universit\u00e0 Cattolica del Sacro Cuore, Policlinico \u201cA. Gemelli\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Licameli","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universit\u00e0 Cattolica del Sacro Cuore, Policlinico \u201cA. Gemelli\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Straface","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Policlinico Abano Terme, Abano Terme (PD), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Universit\u00e0 Cattolica del Sacro Cuore, Policlinico \u201cA. Gemelli\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"6","key":"1","first-page":"433","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"2","first-page":"643","volume-title":"Syphilis","year":"2001"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/1478-7547-6-10"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-200306000-00006"},{"issue":"rr-12","key":"7","first-page":"1","volume":"59","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"14","key":"9","first-page":"413","volume":"59","year":"2010","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.021352"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(11)70104-9"},{"issue":"1","key":"15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00002030-198802000-00008","volume":"2","year":"1988","journal-title":"AIDS"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1K086"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00470-8"},{"issue":"6","key":"18","first-page":"424","volume":"82","year":"2004","journal-title":"Bulletin of the World Health Organization"},{"key":"19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S1045-1870(99)80020-X","volume":"10","year":"1999","journal-title":"Seminars in Pediatric Infectious Diseases"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1086\/342952"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.121541"},{"issue":"12","key":"22","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1177\/000992286700601207","volume":"6","year":"1967","journal-title":"Clinical Pediatrics"},{"key":"23","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1056\/NEJM199011083231902","volume":"323","year":"1990","journal-title":"The New England Journal of Medicine"},{"issue":"12","key":"24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/00006454-198912000-00016","volume":"8","year":"1989","journal-title":"Pediatric Infectious Disease Journal"},{"issue":"4","key":"25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00005176-198409000-00013","volume":"3","year":"1984","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"issue":"2","key":"26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.49.2.285","volume":"49","year":"1972","journal-title":"Pediatrics"},{"key":"27","volume":"4, article 35","year":"1949","journal-title":"Advances in Pediatrics"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1542\/peds.47.1.27","volume":"47","year":"1971","journal-title":"Pediatrics"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012684"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1053\/j.spid.2005.06.005"},{"key":"31","year":"1954"},{"issue":"2","key":"32","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00007611-197902000-00002","volume":"72","year":"1979","journal-title":"Southern Medical Journal"},{"key":"33","first-page":"1724","volume-title":"Syphilis","year":"2004"},{"issue":"1","key":"34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/CMR.8.1.1","volume":"8","year":"1995","journal-title":"Clinical Microbiology Reviews"},{"key":"35","first-page":"581","volume-title":"Syphilis detection tests","year":"2000"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1086\/342108"},{"issue":"5","key":"37","first-page":"895","volume":"78","year":"1991","journal-title":"Obstetrics and Gynecology"},{"issue":"2","key":"38","doi-asserted-by":"crossref","first-page":"97","DOI":"10.7863\/jum.1993.12.2.97","volume":"12","year":"1993","journal-title":"Journal of Ultrasound in Medicine"},{"key":"39","first-page":"595","volume-title":"Syphilis","year":"2003"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00338-X"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01095-09"},{"issue":"3","key":"42","year":"2001","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"9","key":"43","first-page":"731","volume":"25","year":"1996","journal-title":"Journal of Obstetric, Gynecologic, and Neonatal Nursing"},{"issue":"6, article 386","key":"44","volume":"61","year":"1995","journal-title":"Indian Journal of Dermatology, Venereology and Leprology"},{"issue":"3 i","key":"45","first-page":"375","volume":"75","year":"1990","journal-title":"Obstetrics and Gynecology"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00271-3"},{"key":"47","first-page":"87","volume-title":"Antepartum care","year":"2007"}],"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2012\/430585.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2012\/430585.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2012\/430585.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T05:48:46Z","timestamp":1642657726000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/idog\/2012\/430585\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":41,"alternative-id":["430585","430585"],"URL":"https:\/\/doi.org\/10.1155\/2012\/430585","relation":{},"ISSN":["1064-7449","1098-0997"],"issn-type":[{"value":"1064-7449","type":"print"},{"value":"1098-0997","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}