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Cryptogenic antigens release, recognition of pathogenic structure, and metabolic changes generated by both stimuli begin an inflammatory process which in turn activates the immune system amplifying T and B cell responses. The development of relapsing polychondritis after trauma may have a direct association with these events and in turn probably trigger autoimmune phenomena.<\/jats:p>","DOI":"10.1155\/2012\/453698","type":"journal-article","created":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T15:00:42Z","timestamp":1319727642000},"page":"1-3","source":"Crossref","is-referenced-by-count":7,"title":["Local Cartilage Trauma as a Pathogenic Factor in Autoimmunity (One Hypothesis Based on Patients with Relapsing Polychondritis Triggered by Cartilage Trauma)"],"prefix":"10.1155","volume":"2012","author":[{"given":"Carlos A.","family":"Ca\u00f1as","sequence":"first","affiliation":[{"name":"Rheumatology Unit, Fundaci\u00f3n Valle del Lili, ICESI University, Avenida Sim\u00f3n Bol\u00edvar Carrera 98 No.18-49, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1683-1610","authenticated-orcid":true,"given":"Fabio","family":"Bonilla Abad\u00eda","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Fundaci\u00f3n Valle del Lili, ICESI University, Avenida Sim\u00f3n Bol\u00edvar Carrera 98 No.18-49, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.3.281"},{"key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/08820530500232100"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-008-0939-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42440"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2003.11.001"},{"key":"7","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1093\/rheumatology\/ker144","volume":"50","year":"2011","journal-title":"Rheumatology"},{"key":"8","first-page":"545","volume":"64","year":"2005","journal-title":"Annals of the Rheumatic Diseases"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1080\/030097401753180426"},{"issue":"2","key":"10","first-page":"165","volume":"24","year":"2008","journal-title":"Medicina Interna de Mexico"},{"issue":"12","key":"11","first-page":"2716","volume":"30","year":"2003","journal-title":"Journal of Rheumatology"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh186"},{"issue":"2","key":"13","first-page":"78","volume":"36","year":"2011","journal-title":"Acta M\u00e9dica Colombiana"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1080\/08916930500050277"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328346c332"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.016"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0306164"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.11.001"},{"issue":"1","key":"19","first-page":"11","volume":"11","year":"2004","journal-title":"Revista Colombiana De Reumatolog\u00eda"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.02.007"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxh174"},{"issue":"5","key":"22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00371591","volume":"285","year":"1993","journal-title":"Archives of Dermatological Research"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2004.05.012"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.101238"}],"container-title":["Autoimmune Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2012\/453698.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2012\/453698.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2012\/453698.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T04:43:20Z","timestamp":1497933800000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ad\/2012\/453698\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":24,"alternative-id":["453698","453698"],"URL":"https:\/\/doi.org\/10.1155\/2012\/453698","relation":{},"ISSN":["2090-0422","2090-0430"],"issn-type":[{"value":"2090-0422","type":"print"},{"value":"2090-0430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}