{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:56:53Z","timestamp":1762459013438},"reference-count":24,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Arthur Krogh og Hustrus Legat"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anesthesiology Research and Practice"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. To study the safety of autotransfusion following local infiltration analgesia (LIA) with ropivacaine.<jats:italic>Background<\/jats:italic>. Knowledge of blood concentrations of ropivacaine after LIA and autotransfusion is crucial. However, very limited data are available for toxicological risk assessment.<jats:italic>Methods<\/jats:italic>. Autotransfusion was studied in patients after total knee arthroplasty (TKA:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>25<\/mml:mn><\/mml:mrow><\/mml:math>) and total hip arthroplasty (THA:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>27<\/mml:mn><\/mml:mrow><\/mml:math>) with LIA using 200\u2009mg ropivacaine, supplemented with two postoperative bolus injections (150\u2009mg ropivacaine). Drainage blood was reinfused within 6\u2009h postoperatively.<jats:italic>Results<\/jats:italic>. Reinfusion caused a significant increase in the serum concentration of total ropivacaine for TKA from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mn>0.54<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.17<\/mml:mn><\/mml:mrow><\/mml:math>(mean \u00b1 SD) to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mn>0.79<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.20<\/mml:mn><\/mml:mrow><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) and a nonsignificant increase for THA from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mn>0.62<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.17<\/mml:mn><\/mml:mrow><\/mml:math>to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mn>0.63<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>0.18<\/mml:mn><\/mml:mrow><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. The maximum free (unbound) concentration after reinfusion was 0.038\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL. Peak total and free venous ropivacaine concentrations after 8\u2009h and 16\u2009h postoperative bolus injections were 2.6\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL and 0.11\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL, respectively. All concentrations observed were below the threshold for toxicity and no side effects were observed.<jats:italic>Conclusion<\/jats:italic>. Autotransfusion of patients undergoing knee or hip arthroplasty after local infiltration analgesia with 200\u2009mg ropivacaine can be performed safely, even supplemented with 8\u2009h and 16\u2009h postoperative bolus injections.<\/jats:p>","DOI":"10.1155\/2012\/458795","type":"journal-article","created":{"date-parts":[[2012,8,5]],"date-time":"2012-08-05T21:00:52Z","timestamp":1344200452000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty"],"prefix":"10.1155","volume":"2012","author":[{"given":"Torben","family":"Breindahl","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Vendsyssel Hospital, Aalborg University, Bispensgade 37, 9800 Hj\u00f8rring, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery Research Unit, Aalborg Hospital, Aarhus University, Sdr. Skovvej 15, 9000 Aalborg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hindersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Vendsyssel Hospital, Aalborg University, Bispensgade 37, 9800 Hj\u00f8rring, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bjarne","family":"Br\u00f8dsgaard Dencker","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Vendsyssel Hospital, Aalborg University, Barfredsvej 83, 9900 Frederikshavn, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens","family":"Brouw J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Orthopaedic Surgery Research Unit, Aalborg Hospital, Aarhus University, Sdr. 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