{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:32:32Z","timestamp":1791181952845,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"publisher","award":["99-2007-71"],"award-info":[{"award-number":["99-2007-71"]}],"id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"publisher","award":["7-2012-742"],"award-info":[{"award-number":["7-2012-742"]}],"id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"publisher","award":["99-2007-71"],"award-info":[{"award-number":["99-2007-71"]}],"id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008664","name":"Juvenile Diabetes Research Foundation","doi-asserted-by":"publisher","award":["7-2012-742"],"award-info":[{"award-number":["7-2012-742"]}],"id":[{"id":"10.13039\/100008664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["99-2007-71"],"award-info":[{"award-number":["99-2007-71"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["7-2012-742"],"award-info":[{"award-number":["7-2012-742"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008896","name":"Wolfson Family Charitable Trust","doi-asserted-by":"crossref","award":["99-2007-71"],"award-info":[{"award-number":["99-2007-71"]}],"id":[{"id":"10.13039\/501100008896","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008896","name":"Wolfson Family Charitable Trust","doi-asserted-by":"crossref","award":["7-2012-742"],"award-info":[{"award-number":["7-2012-742"]}],"id":[{"id":"10.13039\/501100008896","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Experimental Diabetes Research"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>microRNAs (miRNAs) play important roles in pancreas development and in regulation of insulin expression in the adult. Here we show that loss of miRNAs activity in beta-cells during embryonic development results in lower beta-cell mass and in impaired glucose tolerance. Dicer1-null cells initially constitute a significant portion of the total beta-cell population. However, during postnatal development, Dicer1-null cells are depleted. Furthermore, wild-type beta cells are repopulating the islets in complex compensatory dynamics. Because loss of Dicer1 is also associated with changes in the distribution of membranous E-cadherin, we hypothesized that E-cadherin activity may play a role in beta cell survival or islet architecture. However, genetic loss of E-cadherin function does not impair islet architecture, suggesting that miRNAs likely function through other or redundant effectors in the endocrine pancreas.<\/jats:p>","DOI":"10.1155\/2012\/470302","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T21:27:13Z","timestamp":1346966833000},"page":"1-8","source":"Crossref","is-referenced-by-count":52,"title":["Dysregulation of Dicer1 in Beta Cells Impairs Islet Architecture and Glucose Metabolism"],"prefix":"10.1155","volume":"2012","author":[{"given":"Amitai D.","family":"Mandelbaum","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Melkman-Zehavi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roni","family":"Oren","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Kredo-Russo","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Nir","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuval","family":"Dor","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Hornstein","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611841200"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2337\/db07-1614"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000781"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2007.10.001"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810550106"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2007.00775.x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/nature01957"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.08.079"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2337\/db07-0175"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004212"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.361"},{"key":"13","first-page":"629","volume":"114, part 4","year":"2001","journal-title":"Journal of Cell Science"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90332-W"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.7.1402"},{"issue":"1","key":"16","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2337\/diabetes.51.1.114","volume":"51","year":"2002","journal-title":"Diabetes"},{"issue":"9","key":"17","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1242\/dev.122.9.2895","volume":"122","year":"1996","journal-title":"Development"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.144.2.325"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504834102"},{"issue":"2","key":"20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<139::AID-GENE12>3.0.CO;2-7","volume":"26","year":"2000","journal-title":"Genesis"},{"issue":"1","key":"21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-213X-1-4","volume":"1","year":"2001","journal-title":"BMC Developmental Biology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801689105"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1248505"},{"issue":"1","key":"24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ydbio.2011.09.002","volume":"360","year":"2011","journal-title":"Developmental Biology"},{"issue":"12","key":"25","volume":"6","year":"2011","journal-title":"PLoS ONE"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(02)00090-4"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1159\/000110459"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200422217"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/nature05537"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32959"}],"container-title":["Experimental Diabetes Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2012\/470302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2012\/470302.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jdr\/2012\/470302.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T11:57:29Z","timestamp":1643371049000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jdr\/2012\/470302\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":30,"alternative-id":["470302","470302"],"URL":"https:\/\/doi.org\/10.1155\/2012\/470302","relation":{},"ISSN":["1687-5214","1687-5303"],"issn-type":[{"value":"1687-5214","type":"print"},{"value":"1687-5303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}