{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:48:40Z","timestamp":1760100520511},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,7,12]],"date-time":"2012-07-12T00:00:00Z","timestamp":1342051200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology Research International"],"published-print":{"date-parts":[[2012,7,12]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Our objective was to examine Apo J protein expression in a total of 27 early liveborn neonatal deaths (less than 7 days of age) selected from the Scottish Perinatal Study (gestation of 25\u201342 weeks) comparing a group with histological pontosubicular necrosis (PSN) () to a control group lacking PSN ().<jats:italic>Methods<\/jats:italic>. Using immunohistochemistry we evaluated postmortem pons and hippocampus from patients with PSN versus controls.<jats:italic>Results<\/jats:italic>. In the group with PSN, 11\/12 (92%) cases showed positive Apo J neurones in the hippocampus\/pons compared with 6\/15 (40%) cases without PSN (, odds ratio 27.5, 95% confidence interval 2.881\u2013262.48, using exact logistic regression)\u2014independent of gestation, presence or absence of clinical asphyxia, duration of labour, or postnatal age. Clinical asphyxia was present in 10\/15 (67%) without PSN compared with 11\/12 (92%) with PSN. Neuronal Apo J positivity was present in 15\/21 (71%) of clinically asphyxiated cases compared with 2\/6 (33%) of the cases with no evidence of clinical asphyxia (, odds ratio 5, 95% confidence interval 0.71 to 34.94).<jats:italic>Conclusions<\/jats:italic>. Apo J neuronal protein expression is significantly increased in cases with PSN compared to cases without PSN\u2014independent of gestation, presence of clinical asphyxia, duration of labour, or postnatal age.<\/jats:p>","DOI":"10.1155\/2012\/479359","type":"journal-article","created":{"date-parts":[[2012,7,13]],"date-time":"2012-07-13T18:47:24Z","timestamp":1342205244000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective Case-Control Study of Apolipoprotein J\/Clusterin Protein Expression in Early Liveborn Neonatal Deaths with and without Pontosubicular Necrosis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Kathreena M.","family":"Kurian","sequence":"first","affiliation":[{"name":"Department of Neuropathology, Frenchay Hospital, Frenchay Park Road, Frenchay, Bristol BS16 1LE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan","family":"McGuone","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00852.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2008.01.002"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1992.tb00118.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh436"},{"issue":"12","key":"4","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.1016\/S0021-9258(18)32238-5","volume":"258","year":"1983","journal-title":"The Journal of Biological Chemistry"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1021\/bi952981b"},{"issue":"4","key":"6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0968-0004(92)90325-4","volume":"17","year":"1992","journal-title":"Trends in Biochemical Sciences"},{"issue":"4","key":"7","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/oxfordjournals.jbchem.a123938","volume":"112","year":"1992","journal-title":"Journal of Biochemistry"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(95)00088-A"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(96)00019-8"},{"issue":"4","key":"10","first-page":"325","volume":"3","year":"1994","journal-title":"Neurodegeneration"},{"issue":"4","key":"11","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/neu.480240402","volume":"24","year":"1993","journal-title":"Journal of Neurobiology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90071-G"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/85487"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01588.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s004010100456"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1309\/GQ2R-LNDW-LB9W-Y6UU"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90495-Z"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903390307"},{"issue":"1","key":"28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1098-1136(200007)31:1<39::AID-GLIA40>3.0.CO;2-1","volume":"31","year":"2000","journal-title":"Glia"},{"issue":"3","key":"22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1750-3639.2001.tb00398.x","volume":"11","year":"2001","journal-title":"Brain Pathology"},{"issue":"4","key":"23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/42.4.7510321","volume":"42","year":"1994","journal-title":"Journal of Histochemistry and Cytochemistry"}],"container-title":["Pathology Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/479359.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/479359.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/479359.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T19:55:21Z","timestamp":1714161321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/pri\/2012\/479359\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,12]]},"references-count":22,"alternative-id":["479359","479359"],"URL":"https:\/\/doi.org\/10.1155\/2012\/479359","relation":{},"ISSN":["2090-8091","2042-003X"],"issn-type":[{"value":"2090-8091","type":"print"},{"value":"2042-003X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,12]]}}}