{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:03:37Z","timestamp":1773860617144,"version":"3.50.1"},"reference-count":14,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Child Brain Foundation","award":["POSDRU\/89\/1.5\/S\/60189"],"award-info":[{"award-number":["POSDRU\/89\/1.5\/S\/60189"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Neurological disorders represent major causes of lost years of healthy life and mortality worldwide. Development of their quantitative interdisciplinary<jats:italic>in vivo<\/jats:italic>evaluation is required. Compartment modeling (CM) of brain data acquired<jats:italic>in vivo<\/jats:italic>using magnetic resonance imaging techniques with clinically available contrast agents can be performed to quantitatively assess brain perfusion. Transport of<jats:sup>1<\/jats:sup>H spins in water molecules across physiological compartmental brain barriers in three different pools was mathematically modeled and theoretically evaluated in this paper and the corresponding theoretical compartment modeling of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data was analyzed. The pools considered were blood, tissue, and cerebrospinal fluid (CSF). The blood and CSF data were mathematically modeled assuming continuous flow of the<jats:sup>1<\/jats:sup>H spins in these pools. Tissue data was modeled using three CMs. Results in this paper show that transport across physiological brain barriers such as the blood to brain barrier, the extracellular space to the intracellular space barrier, or the blood to CSF barrier can be evaluated quantitatively. Statistical evaluations of this quantitative information may be performed to assess tissue perfusion, barriers' integrity, and CSF flow<jats:italic>in vivo<\/jats:italic>in the normal or disease-affected brain or to assess response to therapy.<\/jats:p>","DOI":"10.1155\/2012\/482565","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T17:02:47Z","timestamp":1337014967000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Theoretical Compartment Modeling of DCE-MRI Data Based on the Transport across Physiological Barriers in the Brain"],"prefix":"10.1155","volume":"2012","author":[{"given":"Laura","family":"Fanea","sequence":"first","affiliation":[{"name":"Department of Biomedical Physics, Physics Faculty, Babes-Bolyai University, No. 1 M. Kogalniceanu Street, 400084 Cluj-Napoca, Romania"},{"name":"Department of Radiology, Cluj County Emergency Hospital, No. 3-5, Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leontin I.","family":"David","sequence":"additional","affiliation":[{"name":"Department of Biomedical Physics, Physics Faculty, Babes-Bolyai University, No. 1 M. Kogalniceanu Street, 400084 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Lebovici","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cluj County Emergency Hospital, No. 3-5, Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Carbone","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, University of Salerno, Via Ponte Don Melilo, 84084 Fisciano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silviu A.","family":"Sfrangeu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cluj County Emergency Hospital, No. 3-5, Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","year":"2006"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199808000-00068"},{"key":"3","first-page":"20","volume-title":"Flexicover","year":"2005"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","volume":"10","year":"1999","journal-title":"Journal of Magnetic Resonance Imaging"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20684"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20456"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.09.006"},{"issue":"2","key":"9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-3495(81)84845-X","volume":"34","year":"1981","journal-title":"Biophysical Journal"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2006.10.011"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21449"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1186\/1743-8454-7-1"},{"issue":"3","key":"14","first-page":"145","volume":"27","year":"2004","journal-title":"Neurosurgical Review"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20946"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10524"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/482565.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/482565.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2012\/482565.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T14:43:33Z","timestamp":1497969813000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/cmmm\/2012\/482565\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"alternative-id":["482565","482565"],"URL":"https:\/\/doi.org\/10.1155\/2012\/482565","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}