{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:42Z","timestamp":1791156522889,"version":"4.1.0"},"reference-count":30,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical and Developmental Immunology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Utilizing a food allergy murine model, we have investigated the intrinsic antiallergic potential of the<jats:italic>Lactococcus lactis<\/jats:italic>NCC 2287 strain.<jats:italic>Methods<\/jats:italic>. BALB\/c mice were sensitized at weekly intervals with ovalbumin (OVA) plus cholera toxin (CT) by the oral route for 7 weeks. In this model, an oral challenge with a high dose of OVA at the end of the sensitization period leads to clinical symptoms.<jats:italic>Lactococcus lactis<\/jats:italic>NCC 2287 was given to mice via the drinking water during sensitization (prevention phase) or after sensitization (management phase).<jats:italic>Results<\/jats:italic>.<jats:italic>Lactococcus lactis<\/jats:italic>NCC 2287 administration to sensitized mice strikingly reduced allergic manifestations in the management phase upon challenge, when compared to control mice. No preventive effect was observed with the strain.<jats:italic>Lactococcus lactis<\/jats:italic>NCC 2287 significantly decreased relative expression levels of the Th-2 cytokine, IL-13, and associated chemokines CCL11 (eotaxin-1) and CCL17 (TARC) in the ileum. No effect was observed in the jejunum.<jats:italic>Conclusion\/Significance<\/jats:italic>. These results taken together designate<jats:italic>Lactococcus lactis<\/jats:italic>NCC 2287 as a candidate probiotic strain appropriate in the management of allergic symptoms.<\/jats:p>","DOI":"10.1155\/2012\/485750","type":"journal-article","created":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T19:04:13Z","timestamp":1316718253000},"page":"1-10","source":"Crossref","is-referenced-by-count":19,"title":["<i>Lactococcus lactis<\/i>NCC 2287 Alleviates Food Allergic Manifestations in Sensitized Mice by Reducing IL-13 Expression Specifically in the Ileum"],"prefix":"10.1155","volume":"2012","author":[{"given":"Adrian W.","family":"Zuercher","sequence":"first","affiliation":[{"name":"Allergy Group, Department of Nutrition and Health, Nestle Research Center, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland"},{"name":"CSL Behring AG, Wankdorfstra\u00dfe 10, 3010 Bern 22, 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