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Here, we review evidence for genetic and environmental factors that predispose, precipitate, and perpetuate fibromyalgia and depression and include laboratory findings on the role of depression in fibromyalgia. Further, we comment on several aspects of fibromyalgia which support the development of reactive depression, substantially more so than in other chronic pain syndromes. However, while sharing many features with depression, fibromyalgia is associated with somatic comorbidities and absolutely defined by fluctuating spontaneous widespread pain. Fibromyalgia  may, therefore, be more appropriately grouped together with other functional pain disorders, while psychologically distressed subgroups grouped additionally or solely with affective spectrum disorders.<\/jats:p>","DOI":"10.1155\/2012\/486590","type":"journal-article","created":{"date-parts":[[2011,11,19]],"date-time":"2011-11-19T21:00:41Z","timestamp":1321736441000},"page":"1-9","source":"Crossref","is-referenced-by-count":58,"title":["Fibromyalgia and Depression"],"prefix":"10.1155","volume":"2012","author":[{"given":"Richard H.","family":"Gracely","sequence":"first","affiliation":[{"name":"Center for Neurosensory Disorders, University of North Carolina, CBNo.7280, 3330 Thurston Building, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ceko","sequence":"additional","affiliation":[{"name":"Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada"},{"name":"Integrated Program in Neuroscience, McGill University, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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