{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T05:16:34Z","timestamp":1783228594630,"version":"3.54.6"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001502","name":"Department of Atomic Energy, Government of India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001502","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The healing activity of gallic acid enriched ethanolic extract (GAE) of<jats:italic>Phyllanthus emblica<\/jats:italic>fruits (amla) against the indomethacin-induced gastric ulceration in mice was investigated. The activity was correlated with the ability of GAE to alter the cyclooxygenase- (COX-) dependent healing pathways. Histology of the stomach tissues revealed maximum ulceration on the 3rd day after indomethacin (18\u2009mg\/kg, single dose) administration that was associated with significant increase in inflammatory factors, namely, mucosal myeloperoxidase (MPO) activity and inducible nitric oxide synthase (i-NOS) expression. Proangiogenic parameters such as the levels of prostaglandin (PG) E<jats:sub>2<\/jats:sub>, vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), von Willebrand Factor VIII, and endothelial NOS (e-NOS) were downregulated by indomethacin. Treatment with GAE (5\u2009mg\/kg\/day) and omeprazole (3\u2009mg\/kg\/day) for 3 days led to effective healing of the acute ulceration, while GAE could reverse the indomethacin-induced proinflammatory changes of the designated biochemical parameters. The ulcer healing activity of GAE was, however, compromised by coadministration of the nonspecific NOS inhibitor,<jats:italic>N<\/jats:italic>-nitro-L-arginine methyl ester (L-NAME), but not the i-NOS-specific inhibitor, L-<jats:italic>N6<\/jats:italic>-(1-iminoethyl) lysine hydrochloride (L-NIL). Taken together, these results suggested that the GAE treatment accelerates ulcer healing by inducing PGE<jats:sub>2<\/jats:sub>synthesis and augmenting e-NOS\/i-NOS ratio.<\/jats:p>","DOI":"10.1155\/2012\/487380","type":"journal-article","created":{"date-parts":[[2012,8,26]],"date-time":"2012-08-26T21:00:59Z","timestamp":1346014859000},"page":"1-13","source":"Crossref","is-referenced-by-count":36,"title":["Gallic Acid Enriched Fraction of<i>Phyllanthus emblica<\/i>Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway"],"prefix":"10.1155","volume":"2012","author":[{"given":"Ananya","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Biochemistry, University College of Medicine, I.P.G.M.E&R, 244B A.J.C. Bose Road, West Bengal, Kolkata 700020, India"},{"name":"Central Research Laboratory, Department of Biochemistry, KPC Medical College and Hospital, 1F Raja S.C. 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