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The modeling represents an interesting and suitable alternative to models with complex structures that involve the general case of several conditionally independent diagnostic tests, covariates, and strata with different disease prevalences. The technique of stratifying the population according to different disease prevalence rates does not add further marked complexity to the modeling, but it makes the model more flexible and interpretable. To illustrate the general model proposed, we evaluate the performance of six diagnostic screening tests for Chagas disease considering some epidemiological variables. Serology at the time of donation (negative, positive, inconclusive) was considered as a factor of stratification in the model. The general model with stratification of the population performed better in comparison with its concurrents without stratification. The group formed by the testing laboratory Biomanguinhos FIOCRUZ-kit (c-ELISA and rec-ELISA) is the best option in the confirmation process by presenting false-negative rate of 0.0002% from the serial scheme. We are 100% sure that the donor is healthy when these two tests have negative results and he is chagasic when they have positive results.<\/jats:p>","DOI":"10.1155\/2012\/487502","type":"journal-article","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T21:01:09Z","timestamp":1343768469000},"page":"1-12","source":"Crossref","is-referenced-by-count":7,"title":["A General Latent Class Model for Performance Evaluation of Diagnostic Tests in the Absence of a Gold Standard: An Application to Chagas Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"Gilberto de Araujo","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Education and Nursing Community Health, Federal University of Tri\u00e2ngulo Mineiro, 38025-180 Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Louzada","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Statistics, ICMC, University of 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