{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:15:05Z","timestamp":1784330105834,"version":"3.55.0"},"reference-count":91,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathology Research International"],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:p>Beh\u00e7et's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Multiple systemic associations including articular, gastrointestinal, cardiopulmonary, neurologic, and vascular involvement are also observed in BD. Although the etiopathogenesis of the disease remains unknown, increased neutrophil functions such as chemotaxis, phagocytosis, and excessive production of reactive oxygen species (ROS), including superoxide anion, which may be responsible for oxidative tissue damage seen in BD, and also immunological alterations, T lymphocyte abnormalities in both subpopulation and function have been considered to be correlated with the etiopathogenesis of BD. There is some clinical evidence suggesting that emotional stress and hormonal alterations can influence the course and disease activity of BD.<\/jats:p>","DOI":"10.1155\/2012\/493015","type":"journal-article","created":{"date-parts":[[2011,10,2]],"date-time":"2011-10-02T19:02:05Z","timestamp":1317582125000},"page":"1-11","source":"Crossref","is-referenced-by-count":32,"title":["Pathophysiology of the Beh\u00e7et's Disease"],"prefix":"10.1155","volume":"2012","author":[{"given":"\u00dcmit","family":"T\u00fcrsen","sequence":"first","affiliation":[{"name":"Department of Dermatology, School of Medicine, Mersin University, Zeytinlibahce, 33079 Mersin, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01741.x"},{"issue":"6","key":"2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3349\/ymj.1997.38.6.423","volume":"38","year":"1997","journal-title":"Yonsei Medical Journal"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0446-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2004.01685.x"},{"issue":"1\u20134","key":"5","first-page":"263","volume":"40","year":"1983","journal-title":"Psychotherapy and Psychosomatics"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S1575-0922(09)72968-7"},{"key":"7","first-page":"74","volume":"43","year":"2009","journal-title":"Turkderm"},{"issue":"3","key":"8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/ar757","volume":"5","year":"2003","journal-title":"Arthritis Research and Therapy"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0195-x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:95:2:97"},{"issue":"9","key":"11","first-page":"1544","volume":"20","year":"1993","journal-title":"The Journal of Rheumatology"},{"issue":"5","key":"12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/rheumatology\/35.5.424","volume":"35","year":"1996","journal-title":"Rheumatology"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/ard.55.2.128","volume":"55","year":"1996","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/1523-1747.ep12605702","volume":"104","year":"1995","journal-title":"Journal of Investigative Dermatology"},{"issue":"1","key":"15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/08830189709116842","volume":"14","year":"1997","journal-title":"International Reviews of Immunology"},{"issue":"4","key":"16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1128\/IAI.59.4.1434-1441.1991","volume":"59","year":"1991","journal-title":"Infection and Immunity"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02695.x"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1046\/j.1365-2249.1997.3611265.x","volume":"108","year":"1997","journal-title":"Clinical and Experimental Immunology"},{"issue":"5","key":"19","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000267916","volume":"28","year":"1996","journal-title":"Ophthalmic Research"},{"issue":"2","key":"20","first-page":"226","volume":"97","year":"1994","journal-title":"Clinical and Experimental Immunology"},{"issue":"4","key":"21","first-page":"377","volume":"32","year":"2002","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"9","key":"22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s002280100365","volume":"57","year":"2001","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"1","key":"23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3109\/10715769809097874","volume":"28","year":"1998","journal-title":"Free Radical Research"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.197.9"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01415.x"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0612-z"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2001.00251.x"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06003.x"},{"issue":"4","key":"29","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/clinchem\/43.4.553","volume":"43","year":"1997","journal-title":"Clinical Chemistry"},{"issue":"4","key":"30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1001\/archopht.1994.01090160124032","volume":"112","year":"1994","journal-title":"Archives of Ophthalmology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1159\/000018061"},{"issue":"3","key":"32","first-page":"535","volume":"29","year":"2002","journal-title":"The Journal of Rheumatology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1080\/09629350310001599710"},{"issue":"5","key":"34","first-page":"S25","volume":"19","year":"2001","journal-title":"Clinical and Experimental Rheumatology"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200206000-00012"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.6.653"},{"issue":"9","key":"37","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1161\/01.CIR.99.9.1230","volume":"99","year":"1999","journal-title":"Circulation"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(92)90042-M"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70523-2"},{"issue":"2","key":"40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9440(10)65601-5","volume":"153","year":"1998","journal-title":"American Journal of Pathology"},{"issue":"7","key":"41","first-page":"1311","volume":"37","year":"1996","journal-title":"Investigative Ophthalmology and Visual Science"},{"issue":"9","key":"42","first-page":"1785","volume":"31","year":"2004","journal-title":"The Journal of Rheumatology"},{"issue":"6","key":"43","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1152\/jappl.2000.89.6.2382","volume":"89","year":"2000","journal-title":"Journal of Applied Physiology"},{"issue":"12","key":"44","doi-asserted-by":"crossref","first-page":"4080","DOI":"10.1210\/jcem.82.12.4408","volume":"82","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2001.01743.x"},{"issue":"4","key":"46","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1210\/jcem-72-4-773","volume":"72","year":"1991","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"2","key":"47","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2265.1996.666478.x","volume":"44","year":"1996","journal-title":"Clinical Endocrinology"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01626.x"},{"key":"49","volume-title":"Interactions of the endocrine and immune systems","year":"2001"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13492-7"},{"issue":"10","key":"51","first-page":"1829","volume":"22","year":"1995","journal-title":"The Journal of Rheumatology"},{"key":"52","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1749-6632.2002.tb04225.x","volume":"966","year":"2002","journal-title":"Annals of the New York Academy of Sciences"},{"key":"53","first-page":"277","volume":"26","year":"1999","journal-title":"The Journal of Rheumatology"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1191\/096120398678920343"},{"key":"55","first-page":"1508","volume":"25","year":"1998","journal-title":"The Journal of Rheumatology"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199909000-00005"},{"issue":"3","key":"57","first-page":"531","volume":"121","year":"1985","journal-title":"American Journal of Pathology"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01526-7"},{"issue":"4","key":"59","first-page":"S-46","volume":"25","year":"2007","journal-title":"Clinical and Experimental Rheumatology"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(91)90161-Q"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1132"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.348"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1227"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-5155(00)00171-4"},{"issue":"3","key":"65","first-page":"209","volume":"152","year":"2001","journal-title":"Annales de Medecine Interne"},{"key":"66","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s100670050117","volume":"18","year":"1999","journal-title":"Clinical Rheumatology"},{"issue":"3","key":"70","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1177\/112067210701700322","volume":"17","year":"2007","journal-title":"European Journal of Ophthalmology"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700104"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00544.x"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02399.x"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.11.009"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02157.x"},{"issue":"5","key":"76","first-page":"904","volume":"22","year":"1995","journal-title":"The Journal of Rheumatology"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2004.08.034"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-004-0459-6"},{"key":"79","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1046\/j.1365-2230.2002.01090.x","volume":"27","year":"2002","journal-title":"Clinical and Experimental Dermatology"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0886-0"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031994"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199511000-00017"},{"issue":"4827","key":"83","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.2823385","volume":"238","year":"1987","journal-title":"Science"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-0100-6"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01078.x"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03247.x"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2006.10.001"},{"issue":"877","key":"88","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/pgmj.74.877.662","volume":"74","year":"1998","journal-title":"Postgraduate Medical Journal"},{"key":"89","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-100103862"},{"issue":"6","key":"90","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1476-5381.1995.tb15921.x","volume":"115","year":"1995","journal-title":"British Journal of Pharmacology"},{"issue":"2","key":"91","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/S1081-1206(10)61484-6","volume":"93","year":"2004","journal-title":"Annals of Allergy, Asthma and Immunology"},{"issue":"13","key":"92","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1096\/fj.00-0699fje","volume":"15","year":"2001","journal-title":"The FASEB Journal"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0627-z"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016377"}],"container-title":["Pathology Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/493015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/493015.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/493015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T06:50:00Z","timestamp":1607583000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/pri\/2012\/493015\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":91,"alternative-id":["493015","493015"],"URL":"https:\/\/doi.org\/10.1155\/2012\/493015","relation":{},"ISSN":["2090-8091","2042-003X"],"issn-type":[{"value":"2090-8091","type":"print"},{"value":"2042-003X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,1]]}}}