{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T21:51:10Z","timestamp":1725313870309},"reference-count":26,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Otolaryngology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The purpose of this study was to assess the effects of amifostine on submandibular gland histology in patients receiving chemoradiation therapy.<jats:italic>Methods.<\/jats:italic>We conducted a retrospective submandibular gland histologic slide review of HNSCC patients receiving chemoradiation for head and neck squamous cell carcinoma with three different levels of amifostine exposure. We used six scoring parameters: fatty replacement, lobular architecture degeneration, interstitial fibrosis, ductal degeneration, acinar degeneration, and inflammatory component presence.<jats:italic>Results<\/jats:italic>. Differences in gender, tumor stage, amifostine dose, age, number of days after neck dissection, and smoking history (pack years) exposure were not significant between the three groups, although there was a difference between groups in the primary subsite (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.006<\/mml:mn><\/mml:mrow><\/mml:math>). The nonparametric Cuzick's test for histologic parameters with varied amifostine treatment showed no significance among the three groups.<jats:italic>Conclusions<\/jats:italic>. Although patients did not receive a full dose of amifostine due to side effects, varying doses of amifostine had no apparent evident cytoprotective effects in three groups of cancer patients treated with primary chemoradiation.<\/jats:p>","DOI":"10.1155\/2012\/508279","type":"journal-article","created":{"date-parts":[[2012,7,15]],"date-time":"2012-07-15T21:03:39Z","timestamp":1342386219000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["The Effect of Amifostine on Submandibular Gland Histology after Radiation"],"prefix":"10.1155","volume":"2012","author":[{"given":"Jacqueline C.","family":"Junn","sequence":"first","affiliation":[{"name":"New York Medical College, Valhalla, NY 10595, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Sciubba","sequence":"additional","affiliation":[{"name":"The Milton J. 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