{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T02:28:31Z","timestamp":1778898511037,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["257"],"award-info":[{"award-number":["257"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Multiple Sclerosis International"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    <jats:italic>Background.<\/jats:italic>\n                    Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes.\n                    <jats:italic>Objective.<\/jats:italic>\n                    To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology.\n                    <jats:italic>Methods.<\/jats:italic>\n                    In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination.\n                    <jats:italic>Results.<\/jats:italic>\n                    Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>&lt;<\/mml:mo>\n                        <mml:mn>0.001<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    for all subtypes). RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.007<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS:\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.039<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    , PPMS:\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mrow>\n                        <mml:mi>P<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>0.005<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ). Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes.\n                    <jats:italic>Conclusion.<\/jats:italic>\n                    Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings. Furthermore it carves out distinct patterns in different MS subtypes.\n                  <\/jats:p>","DOI":"10.1155\/2012\/530305","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T17:03:21Z","timestamp":1343235801000},"page":"1-10","source":"Crossref","is-referenced-by-count":46,"title":["Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography"],"prefix":"10.1155","volume":"2012","author":[{"given":"Timm","family":"Oberwahrenbrock","sequence":"first","affiliation":[{"name":"NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charit\u00e9 University Medicine Berlin\/Max Delbr\u00fcck Center for Molecular Medicine, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Schippling","sequence":"additional","affiliation":[{"name":"Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (inims), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"Department of Neuroimmunology and Clinical Multiple Sclerosis Research, Neurology Clinic, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius","family":"Ringelstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falko","family":"Kaufhold","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charit\u00e9 University Medicine Berlin\/Max Delbr\u00fcck Center for Molecular Medicine, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charit\u00e9 University Medicine Berlin\/Max Delbr\u00fcck Center for Molecular Medicine, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazmiye","family":"Keser","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Lea","family":"Young","sequence":"additional","affiliation":[{"name":"Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (inims), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Harmel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Peter","family":"Hartung","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical Faculty, Heinrich-Heine-University D\u00fcsseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Martin","sequence":"additional","affiliation":[{"name":"Institute for Neuroimmunology and Clinical Multiple Sclerosis Research (inims), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany"},{"name":"Department of Neuroimmunology and Clinical Multiple Sclerosis Research, Neurology Clinic, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedemann","family":"Paul","sequence":"additional","affiliation":[{"name":"NeuroCure Clinical Research Center and Experimental and Clinical Research Center, Charit\u00e9 University Medicine Berlin\/Max Delbr\u00fcck Center 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