{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:18:31Z","timestamp":1789582711935,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007469","name":"Higher Education Research Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007469","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Thailand\u2019s Office of the Higher Education Commission"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Rhodomyrtus tomentosa<\/jats:italic>(Myrtaceae) has been employed in traditional Thai medicine to treat colic diarrhoea, dysentery, abscesses, haemorrhage, and gynaecopathy. In addition, it has been used to formulate skin-whitening, anti-aging and skin beautifying agents. Ethnomedical activities of this plant may be due its antioxidant property. Hence, the aim of this study was to evaluate both<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>antioxidant activities of<jats:italic>R. tomentosa<\/jats:italic>leaf extract.<jats:italic>In vitro<\/jats:italic>antioxidant activity of the extract was assessed by lipid peroxidation inhibition capacity, ferric reducing antioxidant power, and metal chelating activity.<jats:italic>R. tomentosa<\/jats:italic>extract demonstrated its free radical scavenging effects in concentration dependent manner.<jats:italic>In vivo<\/jats:italic>antioxidant activity of the extract was conducted in Swiss<jats:italic>Albino<\/jats:italic>mice. Levels of thio-barbituric acid reactive substances (TBARS), glutathione (GSH), and the activities of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in blood, liver, and kidney were analyzed using microtitre plate photometer. Administration of CCl<jats:sub>4<\/jats:sub>caused significant increase in TBARS and decrease in GSH, SOD, CAT and GPx levels. In contrast,<jats:italic>R. tomentosa<\/jats:italic>extract (0.8\u2009g\/kg) effectively prevented these alterations and maintained the antioxidant status. The results suggest that<jats:italic>R. tomentosa<\/jats:italic>extract can serve as a potent antioxidant.<\/jats:p>","DOI":"10.1155\/2012\/535479","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:12:25Z","timestamp":1350594745000},"page":"1-8","source":"Crossref","is-referenced-by-count":40,"title":["Acetone Extract from<i>Rhodomyrtus tomentosa<\/i>: A Potent Natural Antioxidant"],"prefix":"10.1155","volume":"2012","author":[{"given":"Goodla","family":"Lavanya","sequence":"first","affiliation":[{"name":"Natural Products Research Centre, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supayang Piyawan","family":"Voravuthikunchai","sequence":"additional","affiliation":[{"name":"Natural Products Research Centre, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand"},{"name":"Department of Microbiology, Prince of Songkla University, Hat Yai, Songkhla 90112, 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