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More than ten cellular receptors are known to participate in picornavirus infection, but experimental evidence of their role in cellular infection has been shown for only about twenty picornavirus types. Three enterovirus types and one parechovirus have experimentally been shown to bind and use integrin receptors in cellular infection. These include coxsackievirus A9 (CV-A9), echovirus 9, and human parechovirus 1 that are among the most common and epidemic human picornaviruses and bind to<jats:italic>\u03b1<\/jats:italic>V-integrins via RGD motif that resides on virus capsid. In contrast, echovirus 1 (E-1) has no RGD and uses integrin<jats:italic>\u03b1<\/jats:italic>2<jats:italic>\u03b2<\/jats:italic>1 as cellular receptor. Endocytosis of CV-A9 has recently been shown to occur via a novel Arf6- and dynamin-dependent pathways, while, contrary to collagen binding, E-1 binds inactive<jats:italic>\u03b2<\/jats:italic>1 integrin and enters via macropinocytosis. In this paper, we review what is known about receptors and endocytosis of integrin-binding human picornaviruses.<\/jats:p>","DOI":"10.1155\/2012\/547530","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T21:02:50Z","timestamp":1354050170000},"page":"1-9","source":"Crossref","is-referenced-by-count":22,"title":["Endocytosis of Integrin-Binding Human Picornaviruses"],"prefix":"10.1155","volume":"2012","author":[{"given":"Pirjo","family":"Merilahti","sequence":"first","affiliation":[{"name":"Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, Finland"},{"name":"Degree Program in Biotechnology and Food Technology, Turku University of Applied Sciences, Lemmink\u00e4isenkatu 30, 20520 Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Turku, Kiinamyllynkatu 13, 20520 Turku, 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