{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:45:16Z","timestamp":1740159916080,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T00:00:00Z","timestamp":1344729600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy Research and Practice"],"published-print":{"date-parts":[[2012,8,12]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The standard initial management of patients with locally advanced pharyngolaryngeal presenting with stridor is tracheostomy. Tracheostomy has been shown to negatively impact cancer-related outcomes. <jats:italic>Methods<\/jats:italic>. Retrospective analysis of prospectively collected data of 9 patients, who underwent induction chemotherapy with the aim of prevention of tracheostomy. Presenting features, time to resolution of stridor, and further management are reported. <jats:italic>Results<\/jats:italic>. Eight out of 9 patient received chemotherapy within 12 hours of presentation with stridor. There were 4 patients each with primary hypopharynx and larynx. The stage was IVA in 6 patients and IVB in 2 patients. In all patients receiving immediate chemotherapy, clinical stridor resolved within 48 hours. The radiological response rate was 62.5%. The median reduction in size of tumor was 37%. \n<jats:italic>Conclusion<\/jats:italic>. Immediate neoadjuvant chemotherapy is a feasible and safe option for patients presenting with early stridor and helps in resolution of stridor and avoiding tracheostomy.<\/jats:p>","DOI":"10.1155\/2012\/549170","type":"journal-article","created":{"date-parts":[[2012,8,12]],"date-time":"2012-08-12T21:00:10Z","timestamp":1344805210000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Induction Chemotherapy in Locally Advanced Pharyngolaryngeal Cancers with Stridor: Is It Feasible and Safe?"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7691-3995","authenticated-orcid":true,"given":"Vijay Maruti","family":"Patil","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Hospital, Mumbai 400012, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanita","family":"Noronha","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Tata Memorial Hospital, 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