{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T14:40:04Z","timestamp":1697812804849},"reference-count":14,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>The aim of this study was to investigate the effect of preemptive pantoprazole infusion on early endoscopic findings in patients with acute ulcer bleeding. Records of 333 patients admitted with acute ulcer bleeding were analyzed. Ulcer bleeders were given either 80\u2009mg bolus of pantoprazole followed by continuous infusion of 8\u2009mg per hour or saline infusion until endoscopy. In 93 patients saline infusion whereas in 240 patients bolus plus infusion of pantoprazole was administrated with mean (\u00b1SD) durations of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mn>5.45<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>12.9<\/mml:mn><\/mml:mrow><\/mml:math>hours and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mn>6.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>13.2<\/mml:mn><\/mml:mrow><\/mml:math>hours, respectively (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.29<\/mml:mn><\/mml:math>). Actively bleeding ulcers were detected in 46\/240 (19.2%) of cases in the pantoprazole group as compared with 23\/93 (24.7%) in the saline infusion group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.26<\/mml:mn><\/mml:math>). Different durations of pantoprazole infusion (0\u20134 hours,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>4 hours, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mo>&gt;<\/mml:mo><\/mml:mrow><\/mml:math>6 hours) had no significant effect on endoscopic and clinical outcome parameters in duodenal ulcer bleeders. Gastric ulcer bleeders on pantoprazole infusion longer than 4 and 6 hours before endoscopy had actively bleeding ulcers in 4.3% and 5% compared to the 19.5% active bleeding rate in the saline group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:math>). Preemptive infusion of high-dose pantoprazole longer than 4 hours before endoscopy decreased the ratio of active bleeding only in gastric but not in duodenal ulcer patients.<\/jats:p>","DOI":"10.1155\/2012\/561207","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T21:11:47Z","timestamp":1350594707000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Pantoprazole before Endoscopy in Patients with Gastroduodenal Ulcer Bleeding: Does the duration of Infusion and Ulcer Location Influence the Effects?"],"prefix":"10.1155","volume":"2012","author":[{"given":"Istvan","family":"R\u00e1cz","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Petz Alad\u00e1r Teaching Hospital, Gy\u0151r 9024, Hungary"},{"name":"Department of Mathematics and Computer Sciences, Sz\u00e9chenyi Istv\u00e1n University, Gy\u0151r 9026, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Szalai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Petz Alad\u00e1r Teaching Hospital, Gy\u0151r 9024, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Dancs","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Petz Alad\u00e1r Teaching Hospital, Gy\u0151r 9024, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tibor","family":"K\u00e1r\u00e1sz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Petz Alad\u00e1r Teaching Hospital, Gy\u0151r 9024, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Petz Alad\u00e1r Teaching Hospital, Gy\u0151r 9024, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaly","family":"Cs\u00f6ndes","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Petz Alad\u00e1r Teaching Hospital, Gy\u0151r 9024, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Horv\u00e1th","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Sciences, Sz\u00e9chenyi Istv\u00e1n University, Gy\u0151r 9026, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"2","key":"1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.7326\/0003-4819-152-2-201001190-00009","volume":"152","year":"2010","journal-title":"Annals of Internal 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