{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:33:16Z","timestamp":1761708796352},"reference-count":100,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells. CMM is in close contact with a peculiar dermal extracellular matrix (ECM). Stromal cells store and release various structural ECM components. The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM products. This paper summarizes some peculiar aspects of the peri-CMM stroma showing intracytoplasmic loads in Factor XIIIa, CD34, versican, and<jats:italic>\u03b1<\/jats:italic>(IV) collagen chains. The restricted peri-CMM skin territory exhibiting such changes corresponds to the area showing neoangiogenesis and extravascular unicellular metastatic spread. The latter inconspicuous migratory CMM cells possibly correspond to CMM stem cells or to CMM cells with aberrant HOX gene expression. Their presence is associated with an increased risk for metastases in the regional sentinel lymph nodes. In conclusion, the CMM-stroma connection appears crucial to the growth regulation, invasiveness and initial metastatic spread of CMM cells. Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells.<\/jats:p>","DOI":"10.1155\/2012\/584219","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T21:00:42Z","timestamp":1340917242000},"page":"1-8","source":"Crossref","is-referenced-by-count":7,"title":["Malignant Melanoma and Its Stromal Nonimmune Microecosystem"],"prefix":"10.1155","volume":"2012","author":[{"given":"G\u00e9rald E.","family":"Pi\u00e9rard","sequence":"first","affiliation":[{"name":"Department of Dermatopathology, Li\u00e8ge University Hospital, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudine","family":"Pi\u00e9rard-Franchimont","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, Li\u00e8ge University Hospital, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Delvenne","sequence":"additional","affiliation":[{"name":"Department of Dermatopathology, Li\u00e8ge University Hospital, 4000 Li\u00e8ge, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1590"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2165\/11318380-000000000-00000"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(01)00620-9"},{"issue":"24","key":"4","first-page":"8939","volume":"63","year":"2003","journal-title":"Cancer Research"},{"issue":"4","key":"5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1085-5629(96)80046-0","volume":"15","year":"1996","journal-title":"Seminars in Cutaneous Medicine and Surgery"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06780.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2007.05.009"},{"issue":"1","key":"8","first-page":"211","volume":"24","year":"2004","journal-title":"International Journal of Oncology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0950-x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2011.221"},{"key":"11"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.040"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1432"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00047586"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.325"},{"issue":"5","key":"16","first-page":"559","volume":"4","year":"1993","journal-title":"Critical Reviews in Oncogenesis"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050053"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1038\/35077241"},{"issue":"6","key":"19","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/ijc.2910540625","volume":"54","year":"1993","journal-title":"International Journal of Cancer"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.0929"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/00313020412331282708"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200504000-00004"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31805048d9"},{"key":"24","first-page":"27","volume":"3","year":"2007","journal-title":"Trends in Cancer Research"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(97)00231-1"},{"issue":"4","key":"26","first-page":"403","volume":"4","year":"1999","journal-title":"International Journal of Molecular Medicine"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1586\/ERA.09.135"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2010.01.001"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27324"},{"issue":"1","key":"30","first-page":"43","volume":"429","year":"1996","journal-title":"Virchows Archiv"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2007.00427.x"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0601"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/nature06489"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000232"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/828146"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/684032"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31819cd0cb"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-1343"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700017"},{"issue":"4-5","key":"40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3233\/CBM-2007-34-505","volume":"3","year":"2007","journal-title":"Cancer Biomarkers"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800720"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181fca894"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/362784"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20706"},{"key":"45","volume":"28, article 13","year":"2008","journal-title":"BMC Medical Genomics"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0366-6999.2010.18.021"},{"key":"47"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-0436.2002.700909.x"},{"issue":"6","key":"49","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00018-003-2178-9","volume":"60","year":"2003","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"1","key":"50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000247986","volume":"180","year":"1990","journal-title":"Dermatologica"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm_00000036"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2008.00994.x"},{"issue":"10","key":"53","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1600-0560.1998.tb01740.x","volume":"25","year":"1998","journal-title":"Journal of Cutaneous Pathology"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb04197.x"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1002\/path.1809"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0667-9"},{"issue":"1","key":"58","first-page":"19","volume":"29","year":"1997","journal-title":"Journal of Submicroscopic Cytology and Pathology"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027002067.x"},{"issue":"1","key":"60","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1365-2559.1994.tb01268.x","volume":"24","year":"1994","journal-title":"Histopathology"},{"issue":"2","key":"61","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0560.1999.tb01806.x","volume":"26","year":"1999","journal-title":"Journal of Cutaneous Pathology"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1999.tb01834.x"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200506000-00004"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00375-7"},{"issue":"2","key":"65","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0002-9440(10)64874-2","volume":"160","year":"2002","journal-title":"American Journal of Pathology"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20813"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3700449"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.68.12.1376"},{"issue":"11","key":"69","first-page":"500","volume":"13","year":"2008","journal-title":"European Journal of Medical Research"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2010.357"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2010.577"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.127522"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M106441200"},{"key":"74","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.142.3.873"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2003.08.006"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(00)00072-4"},{"issue":"3","key":"77","first-page":"204","volume":"7","year":"1997","journal-title":"European Journal of Dermatology"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01706.x"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1159\/000066146"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050115"},{"key":"82","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.6002"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25125"},{"issue":"26","key":"84","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM198612253152606","volume":"315","year":"1986","journal-title":"The New England Journal of Medicine"},{"issue":"4","key":"85","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0560.1997.tb01583.x","volume":"24","year":"1997","journal-title":"Journal of Cutaneous Pathology"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.2174\/156802612798919240"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00500.x"},{"issue":"1","key":"88","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0002-9440(10)63110-0","volume":"164","year":"2004","journal-title":"American Journal of Pathology"},{"key":"90","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0442"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e318032ea5d"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00891.x"},{"issue":"6","key":"93","first-page":"1367","volume":"19","year":"2008","journal-title":"Oncology Reports"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2010.03.015"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1038\/nature05661"},{"issue":"10","key":"96","first-page":"579","volume":"63","year":"2008","journal-title":"Revue Medicale de Liege"},{"key":"97","first-page":"64","volume":"67","year":"2012","journal-title":"Revue M\u00e9dicale de Li\u00e8ge"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200242"},{"key":"99","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1158\/1535-7163.MCT-11-0676","volume":"11","year":"2012","journal-title":"Molecular Cancer Therapy"},{"key":"100","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S21259"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0899-4_14"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1228-2"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1002\/path.1398"}],"container-title":["Journal of Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2012\/584219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2012\/584219.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jo\/2012\/584219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T20:43:39Z","timestamp":1497991419000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jo\/2012\/584219\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":100,"alternative-id":["584219","584219"],"URL":"https:\/\/doi.org\/10.1155\/2012\/584219","relation":{},"ISSN":["1687-8450","1687-8469"],"issn-type":[{"value":"1687-8450","type":"print"},{"value":"1687-8469","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}