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In HCWs, 48%, 51%, and 19% were positive in QFT, TBGL-IgG, and -IgA, respectively. The TBGL-IgG positivity was significantly higher (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) in QFT-positive than QFT-negative HCWs. Both TBGL-IgG- and -IgA-positive cases were only found in QFT-positive HCWs (27%). The plasma IFN-\u03b3 levels positively correlated with TBGL-IgA titers (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.74<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>), but not TBGL-IgG titers in this group, indicating that mucosal immunity is involved in LTBI in immunocompetent individuals. The QFT positivity in HIV-AC was 31% in those with CD4+ cell counts &gt;350\/\u03bcL and 12.5% in low CD4 group (&lt;350\/\u03bcL). 59 % and 29% were positive for TBGL-IgG and -IgA, respectively, in HIV-AC, but no association was found between QFT and TBGL assays. TBGL-IgG-positive rates in QFT-positive and QFT-negative HIV-AC were 61% and 58%, and those of TBGL-IgA were 23% and 30%, respectively. The titers of TBGL-IgA were associated with serum IgA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:math>) in HIV-AC. Elevations of TBGL-IgG and -IgA were related to latent tuberculosis infection in HCWs, but careful interpretation is necessary in HIV-AC.<\/jats:p>","DOI":"10.1155\/2012\/610707","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T21:44:15Z","timestamp":1333662255000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Frequent Detection of Anti-Tubercular-Glycolipid-IgG and -IgA Antibodies in Healthcare Workers with Latent Tuberculosis Infection in the Philippines"],"prefix":"10.1155","volume":"2012","author":[{"given":"Umme Ruman","family":"Siddiqi","sequence":"first","affiliation":[{"name":"Division of Emerging Infectious Diseases, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prisca Susan A.","family":"Leano","sequence":"additional","affiliation":[{"name":"STD AIDS Cooperative Central Laboratory, San Lazaro Hospital, Manila, 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