{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:40:29Z","timestamp":1792075229084,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,6,15]],"date-time":"2012-06-15T00:00:00Z","timestamp":1339718400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["127138"],"award-info":[{"award-number":["127138"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kuopio University Hospital","award":["127138"],"award-info":[{"award-number":["127138"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Drug Delivery"],"published-print":{"date-parts":[[2012,6,15]]},"abstract":"<jats:p>Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of childhood characterized by selective death of cortical neurons. Insulin-like growth factor 1 (IGF-1) is important in embryonic development and is considered as a potential therapeutic agent for several disorders of peripheral and central nervous systems. In circulation IGF-1 is mainly bound to its carrier protein IGFBP-3. As a therapeutic agent IGF-1 has shown to be more active as free than complexed form. However, this may cause side effects during the prolonged treatment. In addition to IGFBP-3 the bioavailability of IGF-1 can be modulated by using mesoporous silicon nanoparticles (NPs) which are optimal carriers for sustained release of unstable peptide hormones like IGF-1. In this study we compared biodistribution, pharmacokinetics, and bioavailability of radiolabeled free IGF-1, IGF-1\/IGFBP-3, and IGF-1\/NP complexes in a <jats:italic>Cln1<\/jats:italic>-\/- knockout mouse model. IGF-1\/NP was mainly accumulated in liver and spleen in all studied time points, whereas minor and more constant amounts were measured in other organs compared to free IGF-1 or IGF-1\/IGFBP-3. Also concentration of IGF-1\/NP in blood was relatively high and stable during studied time points suggesting continuous release of IGF-1 from the particles.<\/jats:p>","DOI":"10.1155\/2012\/626417","type":"journal-article","created":{"date-parts":[[2012,6,16]],"date-time":"2012-06-16T04:22:40Z","timestamp":1339820560000},"page":"1-8","source":"Crossref","is-referenced-by-count":12,"title":["Native and Complexed IGF-1: Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Tuulia","family":"Huhtala","sequence":"first","affiliation":[{"name":"A.I. 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