{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:37:07Z","timestamp":1789749427540,"version":"4.0.1"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Transplantation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Liver ischemia-reperfusion injury is a major cause of primary graft non-function or initial function failure post-transplantation. In this study, we examined the effects of sodium nitrite supplementation on liver IRI in either Lactated Ringer's (LR) solution or University of Wisconsin (UW) solution. The syngeneic recipients of liver grafts were also treated with or without nitrite by intra-peritoneal injection. Liver AST and LDH release were significantly reduced in both nitrite-supplemented LR and UW preservation solutions compared to their controls. The protective effect of nitrite was more efficacious with longer cold preservation times. Liver histological examination demonstrated better preserved morphology and architecture with nitrite treatment. Hepatocellular apoptosis was significantly reduced in the nitrite-treated livers compared their controls. Moreover, liver grafts with extended cold preservation time of 12 to 24 hours demonstrated improved liver tissue histology and function post-reperfusion with either the nitrite-supplemented preservation solution or in nitrite-treated recipients. Interestingly, combined treatment of both the liver graft and recipient did not confer protection. Thus, nitrite treatment affords significant protection from cold ischemic and reperfusion injury to donor livers and improves liver graft acute function post-transplantation. The results from this study further support the potential for nitrite therapy to mitigate ischemia-reperfusion injury in solid organ transplantation.<\/jats:p>","DOI":"10.1155\/2012\/635179","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T16:04:17Z","timestamp":1330445057000},"page":"1-10","source":"Crossref","is-referenced-by-count":21,"title":["The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury"],"prefix":"10.1155","volume":"2012","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[{"name":"Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA"},{"name":"Department of Hepato-Pancreatic Surgery, The Third Hospital of Bethune Medical College (China-Japan Union Hospital), Jilin University, Changchun, Jilin 130033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihui","family":"Meng","sequence":"additional","affiliation":[{"name":"Division of Transplantation, Department of Surgery, University of Washington Medical Center, Seattle, WA 98195, USA"},{"name":"Department of Hepato-Pancreatic Surgery, The Third Hospital of Bethune Medical College (China-Japan Union Hospital), Jilin University, Changchun, Jilin 130033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh P.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pathology and Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9220-565X","authenticated-orcid":true,"given":"John D.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology & Pain Medicine, University of Washington Medical Center, P.O. Box 356540, Seattle, WA 98195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2006"},{"issue":"6","key":"2","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.4049\/jimmunol.168.6.2997","volume":"168","year":"2002","journal-title":"Journal of Immunology"},{"issue":"6","key":"3","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.4049\/jimmunol.176.6.3449","volume":"176","year":"2006","journal-title":"Journal of Immunology"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.10.171"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31892"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200522493"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070198"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.05.037"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2009.11.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/med.20151"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181fcf3cc"},{"issue":"3","key":"13","first-page":"350","volume":"4","year":"2005","journal-title":"Hepatobiliary and Pancreatic Diseases International"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(00)00111-X"}],"container-title":["Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtrans\/2012\/635179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtrans\/2012\/635179.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtrans\/2012\/635179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T10:57:26Z","timestamp":1497956246000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jtrans\/2012\/635179\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":13,"alternative-id":["635179","635179"],"URL":"https:\/\/doi.org\/10.1155\/2012\/635179","relation":{},"ISSN":["2090-0007","2090-0015"],"issn-type":[{"value":"2090-0007","type":"print"},{"value":"2090-0015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}