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The intent of their use is to prevent secondary brain injury by facilitating and optimising ventilation, reducing cerebral metabolic rate and reducing intracranial pressure. There is limited evidence available as to the best choice of sedative agents in TBI, with each agent having specific advantages and disadvantages. This review discusses these agents and offers evidence-based guidance as to the appropriate context in which each agent may be used. Propofol, benzodiazepines, narcotics, barbiturates, etomidate, ketamine, and dexmedetomidine are reviewed and compared.<\/jats:p>","DOI":"10.1155\/2012\/637171","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T17:02:50Z","timestamp":1348160570000},"page":"1-11","source":"Crossref","is-referenced-by-count":88,"title":["Sedation in Traumatic Brain Injury"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-0826","authenticated-orcid":true,"given":"Oliver","family":"Flower","sequence":"first","affiliation":[{"name":"University of Sydney, Sydney, NSW, Australia"},{"name":"Department of Intensive Care, Royal North Shore Hospital, Sydney, NSW 2065, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Hellings","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Royal North Shore Hospital, Sydney, NSW 2065, 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