{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:47:39Z","timestamp":1777045659995,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Onchocerciasis Elimination Program for the Americas"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Parasitology Research"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>In Latin America, onchocerciasis is targeted for elimination by 2012 through twice-yearly mass treatment of the eligible population with ivermectin. In Guatemala, two of the four historical endemic foci have demonstrated elimination of transmission, following World Health Organization guidelines. Using established guidelines ophthalmological, serological, and entomological evaluations were conducted in 2007-8 to determine the transmission status of onchocerciasis in the Huehuetenango focus. The prevalence of<jats:italic>Onchocerca volvulus<\/jats:italic>microfilariae in the anterior segment of the eye in 365 residents was 0% (95% confidence interval [CI] 0\u20130.8%), the prevalence of infection of<jats:italic>O. volvulus<\/jats:italic>in<jats:italic>Simulium ochraceum<\/jats:italic>among 8252 flies collected between November 2007 and April 2008 was 0% (95% CI 0\u20130.02%), and the prevalence of antibodies to a recombinant<jats:italic>O. volvulus<\/jats:italic>antigen in 3118 school age children was 0% (95% CI 0\u20130.1%). These results showed transmission interruption; thus, in 2009 mass treatment was halted and posttreatment surveillance began. To verify for potential recrudescence an entomological evaluation (from December 2010 to April 2011) was conducted during the 2nd and 3rd year of posttreatment surveillance. A total of 4587<jats:italic>S. ochraceum<\/jats:italic>were collected, and the prevalence of infection of<jats:italic>O. volvulus<\/jats:italic>was 0% (95% CI 0\u20130.04%). Transmission of onchocerciasis in the Huehuetenango focus has been eliminated.<\/jats:p>","DOI":"10.1155\/2012\/638429","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T17:01:09Z","timestamp":1345741269000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Elimination of<i>Onchocerca volvulus<\/i>Transmission in the Huehuetenango Focus of Guatemala"],"prefix":"10.1155","volume":"2012","author":[{"given":"Nancy","family":"Cruz-Ortiz","sequence":"first","affiliation":[{"name":"Centro de Estudios en Salud, Universidad del Valle de Guatemala (UVG), 18 avenida 11-95 Zona 15, Vista Hermosa III, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo J.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Salud, Universidad del Valle de Guatemala (UVG), 18 avenida 11-95 Zona 15, Vista Hermosa III, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim A.","family":"Lindblade","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE A-06, Atlanta, GA 30333, USA"},{"name":"CDC Regional Office for Central America and Panama, UVG, 18 avenida 11-95 Zona 15, Vista Hermosa III, Guatemala City, Guatemala"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank O.","family":"Richards","sequence":"additional","affiliation":[{"name":"Carter Center, 453 Freedom Parkway, Atlanta, GA 30307, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Sauerbrey","sequence":"additional","affiliation":[{"name":"Onchocerciasis Elimination Program for the Americas, 14 Calle 3-51 Zona 10, Edificio Murano Center, Oficina 1401, Guatemala City, 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