{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:24:10Z","timestamp":1788870250131,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102730"],"award-info":[{"award-number":["81102730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30902020"],"award-info":[{"award-number":["30902020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173463"],"award-info":[{"award-number":["81173463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011069"],"award-info":[{"award-number":["2011069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102730"],"award-info":[{"award-number":["81102730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30902020"],"award-info":[{"award-number":["30902020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173463"],"award-info":[{"award-number":["81173463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011069"],"award-info":[{"award-number":["2011069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102730"],"award-info":[{"award-number":["81102730"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30902020"],"award-info":[{"award-number":["30902020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173463"],"award-info":[{"award-number":["81173463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2011069"],"award-info":[{"award-number":["2011069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["81102730"],"award-info":[{"award-number":["81102730"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["30902020"],"award-info":[{"award-number":["30902020"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["81173463"],"award-info":[{"award-number":["81173463"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011069"],"award-info":[{"award-number":["2011069"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["81102730"],"award-info":[{"award-number":["81102730"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["30902020"],"award-info":[{"award-number":["30902020"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["81173463"],"award-info":[{"award-number":["81173463"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2011069"],"award-info":[{"award-number":["2011069"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Creation for Significant New Drugs","award":["81102730"],"award-info":[{"award-number":["81102730"]}]},{"name":"Creation for Significant New Drugs","award":["30902020"],"award-info":[{"award-number":["30902020"]}]},{"name":"Creation for Significant New Drugs","award":["81173463"],"award-info":[{"award-number":["81173463"]}]},{"name":"Creation for Significant New Drugs","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}]},{"name":"Creation for Significant New Drugs","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}]},{"name":"Creation for Significant New Drugs","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}]},{"name":"Creation for Significant New Drugs","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}]},{"name":"Creation for Significant New Drugs","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}]},{"name":"Creation for Significant New Drugs","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"Creation for Significant New Drugs","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}]},{"name":"Creation for Significant New Drugs","award":["2011069"],"award-info":[{"award-number":["2011069"]}]},{"name":"International Science and Technology Cooperation of China","award":["81102730"],"award-info":[{"award-number":["81102730"]}]},{"name":"International Science and Technology Cooperation of China","award":["30902020"],"award-info":[{"award-number":["30902020"]}]},{"name":"International Science and Technology Cooperation of China","award":["81173463"],"award-info":[{"award-number":["81173463"]}]},{"name":"International Science and Technology Cooperation of China","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}]},{"name":"International Science and Technology Cooperation of China","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}]},{"name":"International Science and Technology Cooperation of China","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}]},{"name":"International Science and Technology Cooperation of China","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}]},{"name":"International Science and Technology Cooperation of China","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}]},{"name":"International Science and Technology Cooperation of China","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"International Science and Technology Cooperation of China","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}]},{"name":"International Science and Technology Cooperation of China","award":["2011069"],"award-info":[{"award-number":["2011069"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["81102730"],"award-info":[{"award-number":["81102730"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["30902020"],"award-info":[{"award-number":["30902020"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["81173463"],"award-info":[{"award-number":["81173463"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011069"],"award-info":[{"award-number":["2011069"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["81102730"],"award-info":[{"award-number":["81102730"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["30902020"],"award-info":[{"award-number":["30902020"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["81173463"],"award-info":[{"award-number":["81173463"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}]},{"name":"Foundation of Beijing University of Chinese Medicine of Education Ministry of China","award":["2011069"],"award-info":[{"award-number":["2011069"]}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["81102730"],"award-info":[{"award-number":["81102730"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["30902020"],"award-info":[{"award-number":["30902020"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["81173463"],"award-info":[{"award-number":["81173463"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2011069"],"award-info":[{"award-number":["2011069"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Science & Technology Star","award":["81102730"],"award-info":[{"award-number":["81102730"]}]},{"name":"Beijing Science & Technology Star","award":["30902020"],"award-info":[{"award-number":["30902020"]}]},{"name":"Beijing Science & Technology Star","award":["81173463"],"award-info":[{"award-number":["81173463"]}]},{"name":"Beijing Science & Technology Star","award":["2003CB517105"],"award-info":[{"award-number":["2003CB517105"]}]},{"name":"Beijing Science & Technology Star","award":["2011CB505106"],"award-info":[{"award-number":["2011CB505106"]}]},{"name":"Beijing Science & Technology Star","award":["2009ZX09502-018"],"award-info":[{"award-number":["2009ZX09502-018"]}]},{"name":"Beijing Science & Technology Star","award":["2008DFA30610"],"award-info":[{"award-number":["2008DFA30610"]}]},{"name":"Beijing Science & Technology Star","award":["2011JYBZZ-JS090"],"award-info":[{"award-number":["2011JYBZZ-JS090"]}]},{"name":"Beijing Science & Technology Star","award":["2011-CXTD-06"],"award-info":[{"award-number":["2011-CXTD-06"]}]},{"name":"Beijing Science & Technology Star","award":["NCET-11-0607"],"award-info":[{"award-number":["NCET-11-0607"]}]},{"name":"Beijing Science & Technology Star","award":["2011069"],"award-info":[{"award-number":["2011069"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    The aim of this study is to explore a bridge connecting the mechanism basis and macro syndromes of coronary heart disease with experimental animal models. GC-MS technique was used to detect the metabolites of plasma samples in mini swine models with myocardial infarction (MI) and patients with unstable angina (UA). 30 metabolites were detected in the plasma samples of more than 50 percent of model group and control group in swine, while 37 metabolites were found in the plasma samples of UA patients and healthy control group. 21 metabolites in the plasma samples of swine model and 20 metabolites in patients with UA were found of significant value. Among which, 8 shared metabolites were found of low level expression in both swine model and UA patients. Independent Student\u2019s\n                    <jats:italic>t<\/jats:italic>\n                    -test, principal component analysis (PCA), and hierarchicalcluster analysis (HCA) were orderly applied to comprehend inner rules of variables in the data. The 8 shared metabolites could take place of the 21 or 20 metabolites in classification of swine model with MI and UA patients, which could be considered as a bridge connecting the mechanism basis and macrosyndromes of swine model with MI and UA patients.\n                  <\/jats:p>","DOI":"10.1155\/2012\/638723","type":"journal-article","created":{"date-parts":[[2012,5,20]],"date-time":"2012-05-20T17:01:44Z","timestamp":1337533304000},"page":"1-6","source":"Crossref","is-referenced-by-count":10,"title":["Metabolomics-Based Study of Clinical and Animal Plasma Samples in Coronary Heart Disease with Blood Stasis Syndrome"],"prefix":"10.1155","volume":"2012","author":[{"given":"Huihui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangtao","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","year":"1994"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.09.023"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.11.035"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00408-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(03)00077-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/408650"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(99)00150-3"},{"key":"8","first-page":"409","volume":"28","year":"2000","journal-title":"Chinese Journal of Cardiology"},{"key":"9","year":"2002"},{"key":"10","first-page":"520","volume":"6","year":"1991","journal-title":"Clinical Focus"},{"issue":"1","key":"11","first-page":"41","volume":"31","year":"1988","journal-title":"Diabetologia"},{"issue":"7","key":"12","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1093\/clinchem\/29.7.1396","volume":"29","year":"1983","journal-title":"Clinical Chemistry"},{"issue":"1","key":"13","first-page":"87","volume":"27","year":"2011","journal-title":"Chemical Research in Chinese Universities"},{"key":"14","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1038\/81137","volume":"18","year":"2000","journal-title":"Nature Biotechnology"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/638723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/638723.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/638723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T18:15:12Z","timestamp":1594145712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2012\/638723\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":14,"alternative-id":["638723","638723"],"URL":"https:\/\/doi.org\/10.1155\/2012\/638723","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}