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Despite being under constant barrage by the immune system,<jats:italic>E. granulosus<\/jats:italic>modulates antiparasite immune responses and persists in the human hosts with detectable humoral and cellular responses against the parasite.<jats:italic>In vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>immunological approaches, together with molecular biology and immunoproteomic technologies, provided us exciting insights into the mechanisms involved in the initiation of<jats:italic>E. granulosus<\/jats:italic>infection and the consequent induction and regulation of the immune response. Although the last decade has clarified many aspects of host-parasite relationship in human cystic echinococcosis, establishing the full mechanisms that cause the disease requires more studies. Here, we review some of the recent developments and discuss new avenues in this evolving story of<jats:italic>E. granulosus<\/jats:italic>infection in man.<\/jats:p>","DOI":"10.1155\/2012\/639362","type":"journal-article","created":{"date-parts":[[2011,10,31]],"date-time":"2011-10-31T19:01:16Z","timestamp":1320087676000},"page":"1-12","source":"Crossref","is-referenced-by-count":113,"title":["Host-Parasite Relationship in Cystic Echinococcosis: An Evolving Story"],"prefix":"10.1155","volume":"2012","author":[{"given":"Alessandra","family":"Siracusano","sequence":"first","affiliation":[{"name":"Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 00161 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Delunardo","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, 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