{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T22:14:42Z","timestamp":1773440082215,"version":"3.50.1"},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Considered as a rare event, gastric syphilis (GS) is reported as an organic form of involvement. Low incidence of GS emphasizes the importance of histopathological analysis.<jats:italic>Objective<\/jats:italic>. We aim to characterize GS endoscopic aspects in an immunocompetent patient.<jats:italic>Case Report<\/jats:italic>. A 23-year-old man presented with epigastric pain associated with nausea, anorexia, generalized malaise and 11\u2009kg weight loss that started 1 month prior to his clinical consultation. Physical examination was normal except for mild abdominal tenderness in epigastrium. Endoscopy observed diminished gastric expandability and diffuse mucosal lesions, from cardia to pylorus. Gastric mucosa was thickened, friable, with nodular aspect, and associated with ulcers lesions. Gastric biopsies were performed, and histopathological analysis resulted in dense inflammatory infiltration rich in plasmocytes. Syphilis serologies were positive for VDRL and<jats:italic>Treponema pallidum<\/jats:italic>reagents. Immunohistochemical tests were positive for<jats:italic>Treponema pallidum<\/jats:italic>and CD138. The patient was treated with penicillin, leading to resolution of his clinical complaints and endoscopic findings.<jats:italic>Conclusion<\/jats:italic>. Diagnosis suspicion of GS is important in view of its nonspecific presentation. Patients with gastric symptoms that mimic neoplastic disease should be investigated thoroughly based on the fact that clinical, endoscopic, and histological findings can easily be mistaken for lymphoma or plastic linitis.<\/jats:p>","DOI":"10.1155\/2012\/646525","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T21:04:34Z","timestamp":1344546274000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Endoscopic Aspects of Gastric Syphilis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Mariana","family":"Souza Varella Fraz\u00e3o","sequence":"first","affiliation":[{"name":"Gastrointestinal Endoscopy Unit of the Hospital of Clinics of the University of S\u00e3o Paulo Medical School, Avenue Dr. En\u00e9as de Carvalho Aguiar, 255 6\u00b0 Andar do Pr\u00e9dio dos Ambulat\u00f3rios, Cerqueira C\u00e9sar, CEP 05403-000, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago","family":"Guimar\u00e3es Vila\u00e7a","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit of the Hospital of Clinics of the University of S\u00e3o Paulo Medical School, Avenue Dr. En\u00e9as de Carvalho Aguiar, 255 6\u00b0 Andar do Pr\u00e9dio dos Ambulat\u00f3rios, Cerqueira C\u00e9sar, CEP 05403-000, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Olavo Arag\u00e3o Andrade Carneiro","sequence":"additional","affiliation":[{"name":"Gastrointestinal Endoscopy Unit of the Hospital of Clinics of the University of S\u00e3o Paulo Medical School, Avenue Dr. En\u00e9as de Carvalho Aguiar, 255 6\u00b0 Andar do Pr\u00e9dio dos Ambulat\u00f3rios, Cerqueira C\u00e9sar, CEP 05403-000, S\u00e3o Paulo, SP, 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