{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:49:08Z","timestamp":1763599748553,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170587"],"award-info":[{"award-number":["81170587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["81170587"],"award-info":[{"award-number":["81170587"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. Antenatal dexamethasone administration for fetal lung development may impair maternal glucose tolerance. In this study, we investigated whether glucose and insulin levels differed among singleton and twin pregnancies and pregnancies with impaired glucose tolerance (IGT) after treatment with dexamethasone.<jats:italic>Methods<\/jats:italic>. Singleton pregnancies, twin pregnancies, and pregnancies with IGT between 28 and 33 weeks of gestation whose mothers were treated with dexamethasone were enrolled in this study. Exclusion criteria included gestational hypertension, diabetes, renal disorders, and infectious diseases. The fasting plasma glucose and insulin levels were checked before administration and 24\u2009h, 48\u2009h, and 72\u2009h after treatment was completed.<jats:italic>Results<\/jats:italic>. Mean glucose levels were significantly higher in the twin pregnancy and IGT groups at 24\u2009h and 48\u2009h after the administration of dexamethasone than those in the singleton pregnancy group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Although there was no significant difference in glucose levels before administration and 72\u2009h after dexamethasone administration among the three groups, insulin levels in the IGT group were significantly higher (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). Insulin levels in the singleton pregnancy group at 24\u2009h and 48\u2009h after treatment were significantly lower than in the twin and IGT groups.<jats:italic>Conclusion<\/jats:italic>. The effects on maternal fasting blood glucose and insulin levels of dexamethasone administrated to promote fetal lung maturation correlated with embryo number and the presence of IGT.<\/jats:p>","DOI":"10.1155\/2012\/652806","type":"journal-article","created":{"date-parts":[[2012,3,25]],"date-time":"2012-03-25T21:02:10Z","timestamp":1332709330000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Maternal Glucose Metabolism after the Administration of Dexamethasone for Fetal Lung Development"],"prefix":"10.1155","volume":"2012","author":[{"given":"Xu","family":"Jian Yun","sequence":"first","affiliation":[{"name":"Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Zhaoxia","sequence":"additional","affiliation":[{"name":"Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chai","family":"Yun","sequence":"additional","affiliation":[{"name":"Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Qin","sequence":"additional","affiliation":[{"name":"Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yuanyuan","sequence":"additional","affiliation":[{"name":"Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Danqing","sequence":"additional","affiliation":[{"name":"Obstetrical Department, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4","key":"1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1677\/joe.0.0450515","volume":"45","year":"1969","journal-title":"Journal of Endocrinology"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1542\/peds.50.4.515","volume":"50","year":"1972","journal-title":"Pediatrics"},{"key":"3","first-page":"1","volume":"12","year":"1994","journal-title":"NIH Consensus Statement"},{"issue":"6","key":"4","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/humrep\/15.6.1403","volume":"15","year":"2000","journal-title":"Human Reproduction"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0412.2002.810906.x"},{"key":"6","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.2337\/diacare.27.2007.S88","volume":"27","year":"2004","journal-title":"Diabetes Care"},{"issue":"7","key":"7","volume":"42","year":"2007","journal-title":"Chinese Journal of Obstetrics and Gynecology"},{"year":"2009","key":"8"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.004"},{"issue":"12","key":"10","volume":"19","year":"2003","journal-title":"The Journal of Practical Medicine"}],"container-title":["International Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2012\/652806.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2012\/652806.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ije\/2012\/652806.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T05:48:30Z","timestamp":1641534510000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ije\/2012\/652806\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":10,"alternative-id":["652806","652806"],"URL":"https:\/\/doi.org\/10.1155\/2012\/652806","relation":{},"ISSN":["1687-8337","1687-8345"],"issn-type":[{"type":"print","value":"1687-8337"},{"type":"electronic","value":"1687-8345"}],"subject":[],"published":{"date-parts":[[2012]]}}}