{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:39:50Z","timestamp":1791182390266,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>\n                    Thyme (\n                    <jats:italic>Thymus vulgaris<\/jats:italic>\n                    L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient. The effect of\n                    <jats:italic>Thymus vulgaris<\/jats:italic>\n                    essential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and chemotaxis\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In the pleurisy model, TEO, CVL, and thymol significantly inhibited inflammatory edema. However, only TEO and CVL inhibited leukocyte migration. In the\n                    <jats:italic>in vitro<\/jats:italic>\n                    chemotaxis experiment, CVL inhibited leukocyte migration, whereas thymol exerted a potent chemoattractant effect. In the ear edema model, CVL (10\u2009mg\/ear), applied topically, reduced edema formation, exerting a topical anti-inflammatory effect. Thymol did not reduce edema formation but rather presented an irritative response, probably dependent on histamine and prostanoid release. Our data suggest that the antiinflammatory effects of TEO and CVL are attributable to the inhibition of inflammatory edema and leukocyte migration.\n                  <\/jats:p>","DOI":"10.1155\/2012\/657026","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T02:16:47Z","timestamp":1341454607000},"page":"1-10","source":"Crossref","is-referenced-by-count":210,"title":["Effects of Thymol and Carvacrol, Constituents of\n                    <i>Thymus vulgaris<\/i>\n                    L. Essential Oil, on the Inflammatory Response"],"prefix":"10.1155","volume":"2012","author":[{"given":"Fernanda Carolina","family":"Fachini-Queiroz","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutic, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Kummer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Fernanda","family":"Estev\u00e3o-Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dalva de Barros","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Medicine, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joice Maria","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Federal University of Paran\u00e1, 80060-000 Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Grespan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciomar Aparecida","family":"Bersani-Amado","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Kenji Nakamura","family":"Cuman","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, State University of Maring\u00e1, 870020-900 Maring\u00e1, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"263","volume-title":"The medicinal and non-medicinal uses of thyme","year":"2002"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00120-5"},{"issue":"2","key":"3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-0029-1243136","volume":"66","year":"2000","journal-title":"Planta Medica"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/728065"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.04.020"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/10412905.2009.9700218","volume":"21","year":"2009","journal-title":"Journal of Essential Oil 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