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HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection.<\/jats:p>","DOI":"10.1155\/2012\/680841","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T23:44:59Z","timestamp":1349221499000},"page":"1-7","source":"Crossref","is-referenced-by-count":36,"title":["Role of HLA in Hematopoietic Stem Cell Transplantation"],"prefix":"10.1155","volume":"2012","author":[{"given":"Meerim","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Asan Medical Center Children\u2019s Hospital, University of Ulsan College of Medicine, Seoul, Republic of 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