{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:20:51Z","timestamp":1790742051294,"version":"4.1.0"},"reference-count":87,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Shanghai Committee of Science and Technology","award":["08DZ1973900"],"award-info":[{"award-number":["08DZ1973900"]}]},{"name":"Shanghai Committee of Science and Technology","award":["2008ZXJ09004-021"],"award-info":[{"award-number":["2008ZXJ09004-021"]}]},{"name":"China National Science and Technology Foundation","award":["08DZ1973900"],"award-info":[{"award-number":["08DZ1973900"]}]},{"name":"China National Science and Technology Foundation","award":["2008ZXJ09004-021"],"award-info":[{"award-number":["2008ZXJ09004-021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD.<jats:italic>Methods<\/jats:italic>. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula,<jats:italic>Xiao-Tan-Jie-Yu-Fang<\/jats:italic>(XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>123<\/mml:mn><\/mml:mrow><\/mml:math>) and placebo (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>122<\/mml:mn><\/mml:mrow><\/mml:math>) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints.<jats:italic>Results and Discussion<\/jats:italic>. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (<jats:italic>P<\/jats:italic>= 0.001~0.028). More patients in the XTJYF group reported \u201cmuch improved\u201d than the placebo group (<jats:italic>P<\/jats:italic>= 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (<jats:italic>P<\/jats:italic>= 0.001~0.036)), and in sleep quality score (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD.<\/jats:p>","DOI":"10.1155\/2012\/691258","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T15:02:26Z","timestamp":1319036546000},"page":"1-11","source":"Crossref","is-referenced-by-count":15,"title":["A Chinese Herbal Formula to Improve General Psychological Status in Posttraumatic Stress Disorder: A Randomized Placebo-Controlled Trial on Sichuan Earthquake Survivors"],"prefix":"10.1155","volume":"2012","author":[{"given":"Xian-Ze","family":"Meng","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Shanghai Changzheng Hospital, Second 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