{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:10:05Z","timestamp":1762603805444},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T00:00:00Z","timestamp":1355875200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Bioinformatics"],"published-print":{"date-parts":[[2012,12,19]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. HNF-1a is a transcription factor that regulates glucose metabolism by expression in various tissues. <jats:italic>Aim<\/jats:italic>. To dock potential ligands of HNF-1a using docking software <jats:italic>in silico<\/jats:italic>. <jats:italic>Methods<\/jats:italic>. We performed <jats:italic>in silico<\/jats:italic> studies using HNF-1a protein 2GYP\u00b7pdb and the following softwares: ISIS\/Draw 2.5SP4, ARGUSLAB 4.0.1, and HEX5.1. <jats:italic>Observations<\/jats:italic>. The docking distances (in angstrom units: 1 angstrom unit (\u00c5)\u2009=\u20090.1 nanometer or \u2009metres) with ligands in decreasing order are as follows: resveratrol (3.8\u2009\u00c5), aspirin (4.5\u2009\u00c5), stearic acid (4.9\u2009\u00c5), retinol (6.0\u2009\u00c5), nitrazepam (6.8\u2009\u00c5), ibuprofen (7.9\u2009\u00c5), azulfidine (9.0\u2009\u00c5), simvastatin (9.0\u2009\u00c5), elaidic acid (10.1\u2009\u00c5), and oleic acid (11.6\u2009\u00c5). <jats:italic>Conclusion<\/jats:italic>. HNF-1a domain interacted most closely with resveratrol and aspirin\n<\/jats:p>","DOI":"10.1155\/2012\/705435","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T23:02:33Z","timestamp":1355958153000},"page":"1-5","source":"Crossref","is-referenced-by-count":5,"title":["<i>In Silico<\/i> Docking of HNF-1a Receptor Ligands"],"prefix":"10.1155","volume":"2012","author":[{"given":"Gumpeny Ramachandra","family":"Sridhar","sequence":"first","affiliation":[{"name":"Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530 002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Padmanabhuni Venkata","family":"Nageswara Rao","sequence":"additional","affiliation":[{"name":"Department of Computer Science and Engineering, GITAM University, Visakhapatnam 530045, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dowluru SVGK","family":"Kaladhar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Bioinformatics, GITAM University, Visakhapatnam 530045, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatavarthi Uma","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Computer Science, GITAM University, Visakhapatnam 530045, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sali Veeresh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Bioinformatics, GITAM University, Visakhapatnam 530045, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra002168"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1096\/fasebj.10.2.8641560","volume":"10","year":"1996","journal-title":"The FASEB Journal"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304372200"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.491"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0270011"},{"issue":"5377","key":"6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1126\/science.281.5377.692","volume":"281","year":"1998","journal-title":"Science"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1021\/ci049794h"},{"key":"8","first-page":"81","volume":"1","year":"2008","journal-title":"Journal of Computer Science & Systems Biology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm1131"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070140"},{"issue":"7000","key":"11","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nature02789","volume":"430","year":"2004","journal-title":"Nature"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0079"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000467"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169956"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00524-4"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094637"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00126-6"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1177\/1087057106294710"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/nature06261"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2009.06.004"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812931106"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308329476"}],"container-title":["Advances in Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/705435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/705435.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2012\/705435.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T04:57:32Z","timestamp":1607576252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/abi\/2012\/705435\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,19]]},"references-count":22,"alternative-id":["705435","705435"],"URL":"https:\/\/doi.org\/10.1155\/2012\/705435","relation":{},"ISSN":["1687-8027","1687-8035"],"issn-type":[{"value":"1687-8027","type":"print"},{"value":"1687-8035","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,19]]}}}