{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:44:52Z","timestamp":1788428692418,"version":"build-2803163510"},"reference-count":67,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Tanshinone IIA (Tan IIA) is a member of the major lipophilic components extracted from the root of<jats:italic>Salvia miltiorrhiza<\/jats:italic>Bunge, which is currently used in China and other neighboring countries to treat patients suffering from myocardial infarction (MI), angina pectoris, stroke, diabetes, sepsis, and other conditions. However, Tan IIA is not easy to be absorbed through intestinal pathway. To raise the bioavailability of the herb, sodium tanshinone IIA sulfonate (STS) was developed. This paper discussed the pharmacology of Tan IIA, STS, and their potential cardioprotective effects.<\/jats:p>","DOI":"10.1155\/2012\/716459","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T21:01:38Z","timestamp":1328562098000},"page":"1-7","source":"Crossref","is-referenced-by-count":94,"title":["Tanshinone IIA: A Promising Natural Cardioprotective Agent"],"prefix":"10.1155","volume":"2012","author":[{"given":"Qinghua","family":"Shang","sequence":"first","affiliation":[{"name":"Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China"},{"name":"National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0641-2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-011-0659-5"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep056"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.046"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01027.2006"},{"issue":"7","key":"6","first-page":"632","volume":"28","year":"2008","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"issue":"5","key":"7","first-page":"499","volume":"30","year":"2010","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2009.41.7.056"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.06.002"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-008-0197-y"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-008-0509-7"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0006-2952(02)01250-9","volume":"64","year":"2002","journal-title":"Biochemical Pharmacology"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-009-0365-8"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-008-0123-3"},{"issue":"1","key":"15","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/emm.2007.8","volume":"39","year":"2007","journal-title":"Experimental and Molecular Medicine"},{"issue":"4","key":"16","first-page":"602","volume":"18","year":"2003","journal-title":"West China Medical Journal"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2010.03.021"},{"issue":"17","key":"18","first-page":"2146","volume":"33","year":"2008","journal-title":"China Journal of Chinese Materia Medica"},{"issue":"1","key":"19","first-page":"1","volume":"14","year":"1999","journal-title":"West China Journal of Pharmaceutical Sciences"},{"issue":"2","key":"20","first-page":"188","volume":"39","year":"2008","journal-title":"Journal of Sichuan University"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.01.057"},{"issue":"2","key":"22","first-page":"133","volume":"29","year":"2009","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21599"},{"issue":"7","key":"24","first-page":"637","volume":"27","year":"2007","journal-title":"Chinese Journal of Integrated Traditional and Western Medicine"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2007.01.029"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7254.2007.00598.x"},{"issue":"12","key":"27","first-page":"884","volume":"19","year":"2008","journal-title":"China Pharmacy"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.07.038"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.09.025"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2007.01.001"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.05.004"},{"issue":"1","key":"32","first-page":"49","volume":"29","year":"2006","journal-title":"Journal of Chinese Medicinal Materials"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.08.043"},{"issue":"1","key":"34","first-page":"47","volume":"19","year":"1998","journal-title":"Acta Pharmacologica Sinica"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2542"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0322"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.08.010"},{"issue":"3","key":"38","first-page":"269","volume":"12","year":"1991","journal-title":"Acta Pharmacologica Sinica"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2006.04.044"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2009.01.011"},{"issue":"1","key":"41","first-page":"188","volume":"17","year":"2009","journal-title":"Journal of Experimental Hematology"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-45157"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.08.003"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0545"},{"issue":"6","key":"46","first-page":"1171","volume":"38","year":"1996","journal-title":"Biochemistry and Molecular Biology International"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.031"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01447-8"},{"issue":"3","key":"49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/10715760000301471","volume":"33","year":"2000","journal-title":"Free Radical Research"},{"issue":"1","key":"50","first-page":"188","volume":"17","year":"2009","journal-title":"Journal of Experimental Hematology"},{"issue":"1","key":"51","first-page":"39","volume":"5","year":"1984","journal-title":"Acta Pharmacologica Sinica"},{"issue":"1","key":"52","first-page":"55","volume":"37","year":"2006","journal-title":"Journal of Sichuan University"},{"issue":"2","key":"53","first-page":"140","volume":"43","year":"2002","journal-title":"Journal of Traditional Chinese Medicine"},{"issue":"1","key":"54","first-page":"43","volume":"13","year":"1997","journal-title":"Chinese Journal of Pathophysiology"},{"issue":"2","key":"55","first-page":"112","volume":"36","year":"2002","journal-title":"Journal of Harbin Medical University"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00377.x"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.06.005"},{"issue":"1","key":"58","first-page":"9","volume":"17","year":"1995","journal-title":"Foreign Medical Sciences"},{"issue":"2","key":"59","first-page":"93","volume":"17","year":"2005","journal-title":"Qianwei Journal of Medicine & Pharmacy"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1021\/np800119k"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.09.013"},{"issue":"9","key":"62","first-page":"21","volume":"9","year":"2009","journal-title":"Chinese Journal of Information on Traditional Chinese Medicine"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01166.x"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90624-6"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2009.8771"},{"issue":"1","key":"66","first-page":"29","volume":"2","year":"1981","journal-title":"Acta Pharmacologica Sinica"},{"issue":"1","key":"67","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/00029330-200601010-00002","volume":"119","year":"2006","journal-title":"Chinese Medical Journal"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2006.6329"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/716459.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/716459.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2012\/716459.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T07:49:08Z","timestamp":1561276148000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ecam\/2012\/716459\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":67,"alternative-id":["716459","716459"],"URL":"https:\/\/doi.org\/10.1155\/2012\/716459","relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}