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We investigated whether quantitative measurements of lateral ventricular volume and total cortical thickness (a correlate of cerebral atrophy) could be used to more objectively distinguish NPH from normal controls (NC), Alzheimer's (AD), and Parkinson's disease (PD). Volumetric MRIs were obtained prospectively from patients with NPH (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>n<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>5<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), PD (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>n<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>5<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ), and NC (5). Additional NC (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>n<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>5<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ) and AD patients (\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                      <mml:mrow>\n                        <mml:mi>n<\/mml:mi>\n                        <mml:mo>=<\/mml:mo>\n                        <mml:mn>10<\/mml:mn>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    ) from the ADNI cohort were examined. Although mean ventricular volume was significantly greater in the NPH group than all others, the range of values overlapped those of the AD group. Individuals with NPH could be better distinguished when ventricular volume and total cortical thickness were considered in combination. This pilot study suggests that volumetric MRI measurements hold promise for improving NPH differential diagnosis.\n                  <\/jats:p>","DOI":"10.1155\/2012\/718150","type":"journal-article","created":{"date-parts":[[2011,8,7]],"date-time":"2011-08-07T15:01:06Z","timestamp":1312729266000},"page":"1-6","source":"Crossref","is-referenced-by-count":39,"title":["A Pilot Study of Quantitative MRI Measurements of Ventricular Volume and Cortical Atrophy for the Differential Diagnosis of Normal Pressure Hydrocephalus"],"prefix":"10.1155","volume":"2012","author":[{"given":"Dana W.","family":"Moore","sequence":"first","affiliation":[{"name":"Department of Neurology and Neuroscience, Weill Cornell Medical College, 428 East 72nd Street, Suite 500, New York, NY 10021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhami","family":"Kovanlikaya","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Heier","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Radiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaorui","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuroscience, Weill Cornell Medical College, 428 East 72nd Street, Suite 500, New York, NY 10021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King-Wai","family":"Chu","sequence":"additional","affiliation":[{"name":"Mental Illness Research, Education, and Clinical Center, James J. 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