{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T23:03:07Z","timestamp":1708470187481},"reference-count":0,"publisher":"Hindawi Limited","issue":"6","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>Patients with coexisting work-related rhinitis and asthma would benefit from an adequate and simultaneous recognition of both diseases. The present case illustrates the advantages and importance of using an integrated approach to confirm a diagnosis of occupational rhinitis (OR) and occupational asthma (OA).<\/jats:p><jats:p>A 38-year-old woman, who worked as an animal laboratory technician since 2004, first noticed the appearance of rhinitis and conjunctivitis symptoms in 2007 when she was exposed to rats. A skin-prick test with rat extract was strongly positive. A specific inhalation challenge with parallel assessment of nasal and bronchial responses was conducted. After 10 min of exposure, she developed rhinitis and conjunctivitis symptoms, her forced expiratory volume in 1 s dropped by 27.5% and her nasal volume, measured by acoustic rhinometry, decreased by 80% from baseline values. After allergen exposure, induced sputum and nasal lavage examination demonstrated an increase in eosinophils (11% and 20%, respectively). A diagnosis of associated allergic OA and OR was confirmed and she was advised to stop working with rats.<\/jats:p><jats:p>A systematic and parallel diagnostic approach enables confirmation of a diagnosis of OA and OR in patients complaining of work-related rhinitis and asthma symptoms.<\/jats:p>","DOI":"10.1155\/2012\/723049","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T04:03:19Z","timestamp":1458014599000},"page":"385-387","source":"Crossref","is-referenced-by-count":7,"title":["Integrated Approach to Diagnosis of Associated Occupational Asthma and Rhinitis"],"prefix":"10.1155","volume":"19","author":[{"given":"S\u00e9bastien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Respiratory Research Division, Research Center, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Castano","sequence":"additional","affiliation":[{"name":"Respiratory Research Division, Research Center, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Labrecque","sequence":"additional","affiliation":[{"name":"Respiratory Research Division, Research Center, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2012\/723049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2012\/723049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T10:19:04Z","timestamp":1471947544000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crj\/2012\/723049\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"alternative-id":["723049"],"URL":"https:\/\/doi.org\/10.1155\/2012\/723049","relation":{},"ISSN":["1198-2241"],"issn-type":[{"value":"1198-2241","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}