{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:56:34Z","timestamp":1740164194941,"version":"3.37.3"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Paraneoplastic encephalomyelitis (PEM) and subacute sensory neuronopathy (SSN) are remote effects of cancer, usually associated with small-cell lung carcinoma and positive anti-Hu antibody. We describe the rare association of bladder transitional cell carcinoma (TCC) with anti-Hu antibody positivity resulting in this paraneoplastic neurological syndrome.<jats:italic>Patient<\/jats:italic>. A 76-year-old female presented with bilateral muscle weakness and paraesthesia of the upper and lower limbs in a length-dependent \u201cglove and stocking\u201d distribution. Central nervous system symptoms included cognitive problems, personality change, and truncal ataxia. Case notes and the literature were reviewed.<jats:italic>Result<\/jats:italic>. Autoantibody screening was positive for anti-Hu antibody (recently renamed antineuronal nuclear antibody 1, ANNA-1). The diagnosis of PEM and SSN was supported by MRI and lumbar puncture results. A superficial bladder TCC was demonstrated on CT and subsequently confirmed on histology. No other primary neoplasm was found on full-body imaging. The neurological symptoms were considered to be an antibody-mediated paraneoplastic neurological syndrome and improved after resection of the tumour.<jats:italic>Discussion<\/jats:italic>. The association of anti-Hu positive paraneoplastic neurological syndrome and TCC has not been described in the literature previously. We emphasize the need for detailed clinical examination and the importance of a multidisciplinary thought process and encourage further awareness of this rare association.<\/jats:p>","DOI":"10.1155\/2012\/724940","type":"journal-article","created":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T16:04:32Z","timestamp":1356019472000},"page":"1-3","source":"Crossref","is-referenced-by-count":5,"title":["Rare Association of Anti-Hu Antibody Positive Paraneoplastic Neurological Syndrome and Transitional Cell Bladder Carcinoma"],"prefix":"10.1155","volume":"2012","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-7653","authenticated-orcid":true,"given":"S.","family":"Lukacs","sequence":"first","affiliation":[{"name":"St Mary\u2019s Hospital, Imperial NHS Healthcare Trust, Praed Street, City of Westminster, London W2 1NY, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Szabo","sequence":"additional","affiliation":[{"name":"King\u2019s College Hospital NHS Foundation Trust, London SE5 9RS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Woodhams","sequence":"additional","affiliation":[{"name":"Department of Urology, Western Sussex Hospitals NHS Trust, Worthing BN11 2DH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.224105"},{"key":"2","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/brain\/124.6.1138","volume":"124","year":"2001","journal-title":"Brain"},{"issue":"1","key":"4","first-page":"48","volume":"34","year":"2008","journal-title":"Comprehensive Therapy"},{"issue":"6","key":"5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1212\/WNL.59.6.929","volume":"59","year":"2002","journal-title":"Neurology"},{"issue":"10","key":"6","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1212\/WNL.42.10.1938","volume":"42","year":"1992","journal-title":"Neurology"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1212\/WNL.50.3.652","volume":"50","year":"1998","journal-title":"Neurology"},{"volume":"8, article 1e","journal-title":"Perspectives in Health Information Management","year":"2011","key":"7"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2007.04.003"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0002-9343(86)90047-1","volume":"80","year":"1986","journal-title":"American Journal of Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2001.103004248.x"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/WCO.0b013e32834a87b7","volume":"24","year":"2011","journal-title":"Current Opinion in Neurology"}],"container-title":["Case Reports in Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criu\/2012\/724940.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criu\/2012\/724940.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criu\/2012\/724940.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:35:20Z","timestamp":1498005320000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criu\/2012\/724940\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":11,"alternative-id":["724940","724940"],"URL":"https:\/\/doi.org\/10.1155\/2012\/724940","relation":{},"ISSN":["2090-696X","2090-6978"],"issn-type":[{"type":"print","value":"2090-696X"},{"type":"electronic","value":"2090-6978"}],"subject":[],"published":{"date-parts":[[2012]]}}}