{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:29:07Z","timestamp":1773286147425,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100002597","name":"Kyung Hee University","doi-asserted-by":"publisher","award":["KHU-20100679"],"award-info":[{"award-number":["KHU-20100679"]}],"id":[{"id":"10.13039\/501100002597","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Aim<\/jats:italic>. Hyul-bu-chuke-tang (HCEt) is a well-known traditional herbal medicine that is used for the treatment of ischemic cerebrovascular disorders. We investigated the acute effects of HCEt on erythrocyte deformability and cerebrovascular CO<jats:sub>2<\/jats:sub>reactivity (CVR) in healthy male subjects.<jats:italic>Materials and Methods<\/jats:italic>. We examined erythrocyte deformability in an HCEt group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>14<\/mml:mn><\/mml:mrow><\/mml:math>) and a control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:mrow><\/mml:math>). CVR was measured using hyperventilation-induced CO<jats:sub>2<\/jats:sub>reactivity of the middle cerebral artery and transcranial Doppler (TCD) in the HCEt group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>11<\/mml:mn><\/mml:mrow><\/mml:math>). A historical control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>10<\/mml:mn><\/mml:mrow><\/mml:math>) of CVR measurements was also created from our previous study. All measurements were performed prior to and 1, 2, and 3 hours after HCEt administration.<jats:italic>Results<\/jats:italic>. HCEt significantly improved erythrocyte deformability 1 hour after administration compared to the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>2.9<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.1<\/mml:mn><\/mml:mrow><\/mml:math>% versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>-<\/mml:mo><mml:mn>0.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>1.0<\/mml:mn><\/mml:mrow><\/mml:math>%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.034<\/mml:mn><\/mml:mrow><\/mml:math>). HCEt significantly improved the CVR 2 hours after administration compared to the historical control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mn>9.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.0<\/mml:mn><\/mml:mrow><\/mml:math>% versus<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mo>-<\/mml:mo><mml:mn>8.1<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>4.1<\/mml:mn><\/mml:mrow><\/mml:math>%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.007<\/mml:mn><\/mml:mrow><\/mml:math>). The mean blood pressure and pulse rate did not vary from baseline values in either group.<jats:italic>Conclusions<\/jats:italic>. We demonstrated that HCEt improved erythrocyte deformability and CVR. Our findings suggest that an improvement in erythrocyte deformability contributes to HCEt\u2019s effect on cerebral microcirculation.<\/jats:p>","DOI":"10.1155\/2012\/725241","type":"journal-article","created":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T07:14:02Z","timestamp":1338275642000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Effects of Hyul-Bu-Chuke-Tang on Erythrocyte Deformability and Cerebrovascular CO<sub>2<\/sub>Reactivity in Normal Subjects"],"prefix":"10.1155","volume":"2012","author":[{"given":"Woo-Sang","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo-Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, 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Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Uk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Yeon","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Kwan","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Neurologic Diseases, College of Korean Medicine, Kyung Hee University, Seoul 130-702, Republic of 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