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Several studies suggest an important role of NADPH oxidases in different effects mediated by TGF-\u03b2 1. In this study we show that chronic administration of P144, a peptide synthesized from type III TGF-\u03b2 1 receptor, significantly reduced the cardiac NADPH oxidase expression and activity as well as in the nitrotyrosine levels observed in control spontaneously hypertensive rats (V-SHR) to levels similar to control normotensive Wistar Kyoto rats. In addition, P144 was also able to reduce the significant increases in the expression of collagen type I protein and mRNA observed in hearts from V-SHR. In addition, positive correlations between collagen expression, NADPH oxidase activity, and nitrotyrosine levels were found in all animals. Finally, TGF-\u03b2 1-stimulated Rat-2 exhibited significant increases in NADPH oxidase activity that was inhibited in the presence of P144. It could be concluded that the blockade of TGF-\u03b2 1 with P144 inhibited cardiac NADPH oxidase in SHR, thus adding new data to elucidate the involvement of this enzyme in the profibrotic actions of TGF-\u03b2 1.<\/jats:p>","DOI":"10.1155\/2012\/726940","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T15:32:01Z","timestamp":1338823921000},"page":"1-8","source":"Crossref","is-referenced-by-count":15,"title":["Blockade of TGF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mi mathvariant=\"bold-italic\">\u03b2<\/mml:mi><\/mml:math>1 Signalling Inhibits Cardiac NADPH Oxidase Overactivity in Hypertensive Rats"],"prefix":"10.1155","volume":"2012","author":[{"given":"Jos\u00e9 Luis","family":"Miguel-Carrasco","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Sciences, Centre for Applied Medical Research, University of Navarra, 31008 Pamplona, 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