{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:47:02Z","timestamp":1764510422098,"version":"3.37.3"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Hematology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. The outcome of HIV-associated non-Hodgkin lymphoma (NHL) has improved substantially in the highly active antiretroviral therapy (HAART) era. However, HIV-Burkitt lymphoma (BL), which accounts for up to 20% of HIV-NHL, has poor outcome with standard chemotherapy.<jats:italic>Patients and Methods<\/jats:italic>. We retrospectively reviewed HIV-BL treated in the HAART era with the Magrath regimen (CODOX-M\/IVAC<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u00b1<\/mml:mo><\/mml:math>R) at four Canadian centres.<jats:italic>Results<\/jats:italic>. Fourteen patients with HIV-BL received at least one CODOX-M\/IVAC<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u00b1<\/mml:mo><\/mml:math>R treatment. Median age at BL diagnosis was 45.5 years, CD4 count 375 cells\/mL and HIV viral load (VL) &lt;50\u2009copies\/mL. Patients received PCP prophylaxis and G-CSF, 13 received HAART with chemotherapy and 10 rituximab. There were 63 episodes of toxicity, none fatal, including: bacterial infection,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>20<\/mml:mn><\/mml:mrow><\/mml:math>; grade 3-4 hematologic toxicity,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>14<\/mml:mn><\/mml:mrow><\/mml:math>; febrile neutropenia,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>7<\/mml:mn><\/mml:mrow><\/mml:math>; oral thrush; and ifosfamide neurological toxicity,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:math>each. At a median followup of 11.7 months, 12 (86%) patients are alive and in remission. All 10 patients who received HAART, chemotherapy, and rituximab are alive. CD4 counts and HIV VL 6 months following BL therapy completion (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>5<\/mml:mn><\/mml:mrow><\/mml:math>patients) were &gt;250 cells\/mL and undetectable, respectively, in 4.<jats:italic>Conclusion<\/jats:italic>. Intensive chemotherapy with CODOX-M\/IVAC<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\"><mml:mo>\u00b1<\/mml:mo><\/mml:math>R yielded acceptable toxicity and good survival rates in patients with HIV-associated Burkitt lymphoma receiving HAART.<\/jats:p>","DOI":"10.1155\/2012\/735392","type":"journal-article","created":{"date-parts":[[2011,11,14]],"date-time":"2011-11-14T19:03:12Z","timestamp":1321297392000},"page":"1-9","source":"Crossref","is-referenced-by-count":32,"title":["HIV-Associated Burkitt Lymphoma: Good Efficacy and Tolerance of Intensive Chemotherapy Including CODOX-M\/IVAC with or without Rituximab in the HAART Era"],"prefix":"10.1155","volume":"2012","author":[{"given":"J. A.","family":"Rodrigo","sequence":"first","affiliation":[{"name":"Division of Hematology, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada V6T 1Z4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. K.","family":"Hicks","sequence":"additional","affiliation":[{"name":"Division of Hematology, St. Michael's Hospital and the University of Toronto, Toronto, ON, Canada M5S 1A1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Division of Hematology, Sunnybrook Health Sciences Centre and the University of Toronto, Toronto, ON, Canada M5S 1A1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. W.","family":"Song","sequence":"additional","affiliation":[{"name":"Leukemia\/BMT Program of British Columbia, BC Cancer Agency, Vancouver, BC, Canada V5Z 1M9"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ezzat","sequence":"additional","affiliation":[{"name":"Division of Hematology, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada V6T 1Z4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-3753","authenticated-orcid":true,"given":"C. S.","family":"Leger","sequence":"additional","affiliation":[{"name":"Division of Hematology, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada V6T 1Z4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Boro","sequence":"additional","affiliation":[{"name":"Division of Hematology, St. Michael's Hospital and the University of Toronto, Toronto, ON, Canada M5S 1A1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S. 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