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To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) were used as the animal model of chronic hepatic injury. Significantly increased serum catalase and DPPH levels were detected in CCl<jats:sub>4<\/jats:sub>-administrated rats that were treated with OGAE or silymarin as compared to those rats that were treated with saline or CCl<jats:sub>4<\/jats:sub>. In contrast, significantly decreased stress proteins including HSP70 and iNOS were observed in livers of CCl<jats:sub>4<\/jats:sub>-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl<jats:sub>4<\/jats:sub>. Moreover, significant decreases of MMP-9\/MMP-2 ratio, uPA, phosphorylated ERK (p-ERK) and NF-<jats:italic>\u03ba<\/jats:italic>B (p-P65) were detected in livers of CCl<jats:sub>4<\/jats:sub>-administrated rats that were treated with OGAE or sylimarin as compared to those rats that were treated with saline or CCl<jats:sub>4<\/jats:sub>. These findings imply that OGAE can efficiently inhibit CCl<jats:sub>4<\/jats:sub>-induced liver injuries in rats and may therefore be a potential food or herb for preventing liver injuries.<\/jats:p>","DOI":"10.1155\/2012\/736752","type":"journal-article","created":{"date-parts":[[2012,6,27]],"date-time":"2012-06-27T22:10:25Z","timestamp":1340835025000},"page":"1-9","source":"Crossref","is-referenced-by-count":15,"title":["Beneficial Effects of<i>Ocimum gratissimum<\/i>Aqueous Extract on Rats with CCl<sub>4<\/sub>-Induced Acute Liver Injury"],"prefix":"10.1155","volume":"2012","author":[{"given":"Chun-Ching","family":"Chiu","sequence":"first","affiliation":[{"name":"Institute of Microbiology and Immunology, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Department of Neurology and Department of Medical Intensive Care Unit, Chunghua Christian Hospital, Chunghua 500, 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