{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:11:16Z","timestamp":1790565076642,"version":"4.1.0"},"reference-count":16,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Transplantation"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>We report a case of fulminant liver failure resulting in emergent liver transplantation following 3 weeks of nausea, vomiting, and malaise from Jamaican Vomiting Sickness. Jamaican Vomiting Sickness is caused by ingestion of the unripe arils of the Ackee fruit, its seeds and husks. It is characterized by acute gastrointestinal illness and hypoglycemia. In severe cases, central nervous system depression can occur. In previous studies, histologic sections taken from patients with Jamaican Vomiting Sickness have shown hepatotoxicity similar to that seen in Reye syndrome and\/or acetaminophen toxicity. We highlight macroscopic and microscopic changes in the liver secondary to hepatoxicity of Ackee fruit versus those caused by a previously unknown sickle cell trait. We discuss the clinical variables and the synergistic hepatotoxic effect of Ackee fruit and ischemic injury from sickled red blood cells, causing massive hepatic necrosis in this patient.<\/jats:p>","DOI":"10.1155\/2012\/739238","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T21:02:26Z","timestamp":1349730146000},"page":"1-4","source":"Crossref","is-referenced-by-count":4,"title":["Fulminant Hepatic Failure Attributed to Ackee Fruit Ingestion in a Patient with Sickle Cell Trait"],"prefix":"10.1155","volume":"2012","author":[{"given":"Dianne E.","family":"Grunes","sequence":"first","affiliation":[{"name":"Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irini","family":"Scordi-Bello","sequence":"additional","affiliation":[{"name":"Office of the Chief Medical Examiner, 520 First Avenue, New York, NY 10016, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"Florman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Isabel","family":"Fiel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swan N.","family":"Thung","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mount Sinai School of Medicine, One Gustave L. Levy Place, P.O. Box 1194, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00034983.1916.11684104","volume":"10","year":"1916","journal-title":"Annals of Tropical Medicine and Parasitology"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/173356b0"},{"issue":"9","key":"3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1056\/NEJM197608262950901","volume":"295","year":"1976","journal-title":"The New England Journal of Medicine"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1080\/15563650600584410"},{"issue":"5","key":"5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/17843286.1990.11718105","volume":"45","year":"1990","journal-title":"Acta Clinica Belgica"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01088-0"},{"key":"7","first-page":"243","volume":"1","year":"1952","journal-title":"West Indian Medical Journal"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2009.03.002"},{"issue":"5","key":"9","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0196-0644(94)70112-1","volume":"23","year":"1994","journal-title":"Annals of Emergency Medicine"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(84)90265-1"},{"key":"11","first-page":"99","volume":"92","year":"1953","journal-title":"The Johns Hopkins Medical Journal"},{"issue":"5","key":"12","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/00007611-197705000-00008","volume":"70","year":"1977","journal-title":"Southern Medical Journal"},{"issue":"6","key":"13","first-page":"292","volume":"311","year":"1996","journal-title":"The American Journal of the Medical Sciences"},{"key":"15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00000441-196502000-00006","volume":"249","year":"1965","journal-title":"The American Journal of the Medical Sciences"},{"issue":"6","key":"16","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/0016-5085(86)90276-3","volume":"90","year":"1986","journal-title":"Gastroenterology"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.140.10.1364"}],"container-title":["Case Reports in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crit\/2012\/739238.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crit\/2012\/739238.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crit\/2012\/739238.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T01:08:40Z","timestamp":1498007320000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crit\/2012\/739238\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"alternative-id":["739238","739238"],"URL":"https:\/\/doi.org\/10.1155\/2012\/739238","relation":{},"ISSN":["2090-6943","2090-6951"],"issn-type":[{"value":"2090-6943","type":"print"},{"value":"2090-6951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}