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Several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase. However, it is very difficult to prepare a diverse range of sugar derivatives by chemical synthesis or by the isolation of natural products. In addition, the pathogenic capsular polysaccharides of bacteria are carbohydrate antigens, for which a safe and efficacious method of vaccination is required. Phage-display technology has been improved to enable the identification of peptides that bind to carbohydrate-binding proteins, such as lectins and antibodies, from a large repertoire of peptide sequences. These peptides are known as \u201ccarbohydrate-mimetic peptides (CMPs)\u201d because they mimic carbohydrate structures. Compared to carbohydrate derivatives, it is easy to prepare mono- and multivalent peptides and then to modify them to create various derivatives. Such mimetic peptides are available as peptide inhibitors of carbohydrate-protein interactions and peptide mimotopes that are conjugated with adjuvant for vaccination.<\/jats:p>","DOI":"10.1155\/2012\/740982","type":"journal-article","created":{"date-parts":[[2012,10,11]],"date-time":"2012-10-11T11:17:27Z","timestamp":1349954247000},"page":"1-15","source":"Crossref","is-referenced-by-count":24,"title":["Potential of Peptides as Inhibitors and Mimotopes: Selection of Carbohydrate-Mimetic Peptides from Phage Display Libraries"],"prefix":"10.1155","volume":"2012","author":[{"given":"Teruhiko","family":"Matsubara","sequence":"first","affiliation":[{"name":"Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kouhoku, Yokohama 223-8522, 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