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The objective of this study was to characterize the MRI signature of CLs to help interpret the changes seen<jats:italic>in vivo<\/jats:italic>and elucidate the factors limiting their visualization. A quantitative 3D high-resolution (350\u2009<jats:italic>\u03bc<\/jats:italic>m isotropic) MRI study at 3 Tesla of a fixed<jats:italic>post mortem<\/jats:italic>cerebral hemisphere from a patient with MS is presented in combination with matched immunohistochemistry. Type III subpial lesions are characterized by an increase in T1, T2 and M0, and a decrease in MTR in comparison to the normal appearing cortex (NAC). All quantitative MR parameters were associated with cortical GM myelin content, while T1 showed the strongest correlation. The histogram analysis showed extensive overlap between CL and NAC for all MR parameters and myelin content. This is due to the poor contrast in myelin content between CL and NAC in comparison to the variability in myelo-architecture throughout the healthy cortex. This latter comparison is highlighted by the representation of T1 times on cortical surfaces at several laminar depths.<\/jats:p>","DOI":"10.1155\/2012\/742018","type":"journal-article","created":{"date-parts":[[2012,11,18]],"date-time":"2012-11-18T16:00:30Z","timestamp":1353254430000},"page":"1-13","source":"Crossref","is-referenced-by-count":28,"title":["Quantitative Magnetic Resonance Imaging of Cortical Multiple Sclerosis Pathology"],"prefix":"10.1155","volume":"2012","author":[{"given":"Christine L.","family":"Tardif","sequence":"first","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry J.","family":"Bedell","sequence":"additional","affiliation":[{"name":"Small Animal Imaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon F.","family":"Eskildsen","sequence":"additional","affiliation":[{"name":"Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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