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The traditional concept of psoriasis as the \u201chealthy people\u2019s\u201d disease has been recently revised because of ever-increasing reports of associations with various pathological conditions (hypertension, Crohn\u2019s disease, type II diabetes mellitus, obesity, dyslipidemia, metabolic syndrome, infectious conditions). Particularly, advances in psoriasis therapies have introduced biologic agents. All the tumor necrosis factor-alpha inhibitors are associated with an increased risk of developing active disease in patients with latent tuberculosis infection, because of TNF-<jats:italic>\u03b1<\/jats:italic>key role against<jats:italic>Mycobacterium tuberculosis<\/jats:italic>. For this reason, exclusion of active tuberculosis and treatment of latent tuberculosis infection are clinical imperatives prior to starting this therapy. 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