{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T17:43:37Z","timestamp":1648921417876},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Biomedical Imaging"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Rationale and Objectives<\/jats:italic>. Testing a quantitative, noninvasive method to assess postangioplasty vessel wall changes in an animal model.<jats:italic>Material and Methods<\/jats:italic>. Six New Zealand white rabbits were subjected to atherosclerotic injury, including cholesterol-enriched diet, deendothelialization, and percutaneous transluminal angioplasty (PTA) in the distal part of abdominal aorta (four weeks after deendothelialization). The animals were examined with a 1.5T MRI scanner at three times as follows: baseline (six weeks after diet start and two days after PTA) and four weeks and 10 weeks after-PTA. Inflow angiosequence (M2DI) and proton-density-weighted sequence (PDW) were performed to examine the aorta with axial slices. To identify the inner and outer vessel wall boundaries, a dynamic contour algorithm (Gradient Vector Flow Snakes) was applied to the images, followed by calculation of the vessel wall dimensions. The results were compared with histopathological analysis.<jats:italic>Results<\/jats:italic>. The wall thickness in the lesion was significantly higher than in the control region at 4 and 10 weeks, reflecting induction of experimentally created after-angioplasty lesion. At baseline, no significant difference between the two regions was present.<jats:italic>Conclusions<\/jats:italic>. It is possible to follow the development of vessel wall changes after-PTA with MRI in this rabbit model.<\/jats:p>","DOI":"10.1155\/2012\/747264","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T23:03:59Z","timestamp":1355958239000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Postangioplasty Restenosis Followed with Magnetic Resonance Imaging in an Atherosclerotic Rabbit Model"],"prefix":"10.1155","volume":"2012","author":[{"given":"Mari","family":"H\u00e4nni","sequence":"first","affiliation":[{"name":"Department of Radiology, Oncology, and Radiation Science, Section of Radiology, Uppsala University, 751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Lepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Uppsala University Hospital, 751 85 Uppsala, 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