{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:30:36Z","timestamp":1761129036437,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["5U2RTW 006885"],"award-info":[{"award-number":["5U2RTW 006885"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Science and Technology in Tuberculosis","award":["5U2RTW 006885"],"award-info":[{"award-number":["5U2RTW 006885"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. We investigated IFN-<jats:italic>\u03b3<\/jats:italic>levels before and after a six month course of isoniazid among individuals with latent tuberculosis infection (LTBI) in a high-transmission setting.<jats:italic>Design<\/jats:italic>. A total of 26 household contacts of pulmonary tuberculosis patients who were positive for LTBI by tuberculin skin test completed six months of treatment and submitted a blood sample for a follow-up examination. The IFN-<jats:italic>\u03b3<\/jats:italic>response to<jats:italic>Mycobacterium tuberculosis<\/jats:italic>-specific antigens was measured, and the results before and after the completion of LTBI treatment were compared.<jats:italic>Results<\/jats:italic>. Of the 26 study participants, 25 (96%) showed an IFN-<jats:italic>\u03b3<\/jats:italic>level higher than their baseline level before treatment (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>\u2264<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). Only one individual had a decreased IFN-<jats:italic>\u03b3<\/jats:italic>level after treatment but remained positive for LTBI.<jats:italic>Conclusion<\/jats:italic>. In a high-transmission setting, the IFN-<jats:italic>\u03b3<\/jats:italic>level has increased after LTBI treatment. Further studies must be undertaken to understand if this elevation is transient.<\/jats:p>","DOI":"10.1155\/2012\/757152","type":"journal-article","created":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T16:21:37Z","timestamp":1355761297000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["Levels of Interferon-Gamma Increase after Treatment for Latent Tuberculosis Infection in a High-Transmission Setting"],"prefix":"10.1155","volume":"2012","author":[{"given":"Iukary","family":"Takenami","sequence":"first","affiliation":[{"name":"Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gon\u00e7alo Moniz Research Center, Salvador, Bahia 40296 710, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brook","family":"Finkmoore","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alm\u00e9rio","family":"Machado","sequence":"additional","affiliation":[{"name":"Bahia School of Medicine and Public Health, Salvador, Bahia 40290 000, Brazil"},{"name":"Hospital Especializado Oct\u00e1vio Mangabeira, Secretary of Health of Bahia State, Salvador, Bahia 40320 350, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Emodi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee W.","family":"Riley","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases & Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio","family":"Arruda","sequence":"additional","affiliation":[{"name":"Advanced Laboratory of Public Health, Oswaldo Cruz Foundation, Gon\u00e7alo Moniz Research Center, Salvador, Bahia 40296 710, Brazil"},{"name":"Bahia School of Medicine and Public Health, Salvador, Bahia 40290 000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"9235","key":"1","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0140-6736(00)02742-2","volume":"356","year":"2000","journal-title":"The Lancet"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01206-X"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2008.01.002"},{"issue":"3","key":"4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-149-3-200808050-00241","volume":"149","year":"2008","journal-title":"Annals of Internal 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