{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:33:31Z","timestamp":1762659211195,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the capacity of chronic ASA therapy to prevent cardiac alterations and increased oxidative stress in cardiomyopathic hamsters.<jats:italic>Methods and Results<\/jats:italic>. Male Syrian cardiomyopathic and age-matched inbred control hamsters received ASA orally from the age of 60 days. Animals were sacrificed at the age of 150, 250, and 350 days to evaluate the time course of cardiac hypertrophy and cardiovascular tissue superoxide anion (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>) production. At the age of 150 days, the ventricular weight over body weight ratio, resting heart rate, and cardiovascular<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>production were much higher in cardiomyopathic hamsters than those in control. At the age of 250 days, in addition to the continual deterioration of these parameters with age, the blood pressure started to fall and the signs of heart failure appeared. In these cardiomyopathic hamsters, chronic ASA treatment (a) completely prevented elevated<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>O<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>-<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>production and the NAD(P)H oxidase activity, (b) significantly slowed down the development of the cardiac hypertrophy and fibrosis.<jats:italic>Conclusions<\/jats:italic>. Chronic ASA treatment significantly prevents the deterioration of cardiac function and structure as well as the increased oxidative stress in the cardiomyopathic hamster. Our findings suggest that ASA presents a therapeutic potential to prevent cardiac dysfunction.<\/jats:p>","DOI":"10.1155\/2012\/761710","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T02:16:54Z","timestamp":1341454614000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["Protective Effects of Aspirin from Cardiac Hypertrophy and Oxidative Stress in Cardiomyopathic Hamsters"],"prefix":"10.1155","volume":"2012","author":[{"given":"Rong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Pavillon Roger-Gaudry, 2900 Edouard Montpetit, Montr\u00e9al QC, Canada H3T 1J4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Pavillon Roger-Gaudry, 2900 Edouard Montpetit, Montr\u00e9al QC, Canada H3T 1J4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Sadekova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Pavillon Roger-Gaudry, 2900 Edouard Montpetit, Montr\u00e9al QC, Canada H3T 1J4"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian F.","family":"Deschepper","sequence":"additional","affiliation":[{"name":"Clinical Research Institute of Montreal (CRIM), 110 Pine Ave. West, Montr\u00e9al QC, Canada H2W 1R7"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"de Champlain","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine, Universit\u00e9 de Montr\u00e9al, Pavillon Roger-Gaudry, 2900 Edouard Montpetit, Montr\u00e9al QC, Canada H3T 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