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The eye was thought to lack lymphatic vessels except for the conjunctiva; however, advances in the field, including the identification of lymphatic endothelial markers (e.g., LYVE-1 or podoplanin) and lymphangiogenic factors (e.g., VEGF-C), have revealed the exsitence and possible roles of lymphatics and lymphangiogenesis in the eye. Recent studies have shown that corneal limbus, ciliary body, lacrimal gland, orbital meninges, and extraocular muscles contain lymphatic vessels and that the choroid might have a lymphatic-like system. There is no known lymphatic outflow from the eye. However, several lymphatic channels including uveolymphatic pathway might serve the ocular fluid homeostasis. Furthermore, lymphangiogenesis plays important roles in pathological conditions in the eye including corneal transplant rejection and ocular tumor progression. Yet, the role of lymphangiogenesis in most eye diseases, especially inflammatory disease or edema, remains unknown. A better understanding of lymphatic and lymphangiogenesis in the eye will open new therapeutic opportunities to prevent vision loss in ocular diseases.<\/jats:p>","DOI":"10.1155\/2012\/783163","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T20:43:56Z","timestamp":1330980236000},"page":"1-11","source":"Crossref","is-referenced-by-count":81,"title":["Lymphatics and Lymphangiogenesis in the Eye"],"prefix":"10.1155","volume":"2012","author":[{"given":"Shintaro","family":"Nakao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hafezi-Moghadam","sequence":"additional","affiliation":[{"name":"Functional and Molecular Imaging Center and Department of Radiology, Brigham and Women\u02bcs Hospital, Harvard Medical School, Boston, MA 02115, 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