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PH with chronic hepatitis was induced by carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) in rats. The model was confirmed with elevated portal pressures and increased serum CD163 levels. The inducible nitric oxide synthase (iNOS) or heme oxygenase-1 (HO-1) in portal triads was assessed. The isolated portal perfused rat liver (IPPRL) was performed at<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>d<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>0<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>d<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>28<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>d<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>56<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi>d<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>84<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>in the progression of chronic hepatitis. After constricting with phenylephrine, the portal veins were relaxed with Sal B. The EC<jats:sub>50<\/jats:sub>of Sal B for relaxing portal veins was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mo>\u2212<\/mml:mo><mml:mn>2.04<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mn>10<\/mml:mn><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn>7.28<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mn>10<\/mml:mn><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>11<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn>1.52<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mn>10<\/mml:mn><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>11<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>, and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn>8.44<\/mml:mn><mml:mo>\u00d7<\/mml:mo><mml:msup><mml:mn>10<\/mml:mn><mml:mrow><mml:mo>\u2212<\/mml:mo><mml:mn>11<\/mml:mn><\/mml:mrow><\/mml:msup><\/mml:math>\u2009mol\/L at<jats:italic>d<\/jats:italic><jats:sub>0<\/jats:sub>,<jats:italic>d<\/jats:italic><jats:sub>28<\/jats:sub>,<jats:italic>d<\/jats:italic><jats:sub>56<\/jats:sub>, and<jats:italic>d<\/jats:italic><jats:sub>84<\/jats:sub>, respectively. More macrophages infiltrated in portal triads and expressed more iNOS or HO-1 as PH advanced. The areas under the curve (AUCs) of Sal B for reducing PH were positively correlated with the levels of iNOS or HO-1 in portal triads, and so did with serum CD163 levels. Sal B reduces PH in IPPRL with chronic hepatitis, via promoting portal relaxation due to macrophage-originated NO or CO in portal triads, partly at least.<\/jats:p>","DOI":"10.1155\/2012\/786365","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T12:05:08Z","timestamp":1350561908000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Salvianolic Acid B Reducing Portal Hypertension Depends on Macrophages in Isolated Portal Perfused Rat Livers with Chronic Hepatitis"],"prefix":"10.1155","volume":"2012","author":[{"given":"Xin","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Jia","sequence":"additional","affiliation":[{"name":"Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking 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