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The goal of the present paper was to include the flow in the coronary ostia in the previous fluid structure interaction model we have developed and to analyze the effect of diseased tissues (aortic root stiffening and CAS) on coronary perfusion. Results revealed a significant impact on the coronary perfusion due to a moderate increase in the aortic wall stiffness and CAS (increase of the aortic valve leaflets thickness). A marked drop of coronary peak velocity occurred when the values of leaflet thickness and aortic wall stiffness were above a certain threshold, corresponding to a threefold of their normal value. Consequently, mild and prophylactic treatments such as smoking cessation, exercise, or diet, which have been proven to increase the aortic compliance, may significantly improve the coronary perfusion.<\/jats:p>","DOI":"10.1155\/2012\/791686","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T20:44:21Z","timestamp":1330980261000},"page":"1-10","source":"Crossref","is-referenced-by-count":19,"title":["Therapeutic Vascular Compliance Change May Cause Significant Variation in Coronary Perfusion: A Numerical Study"],"prefix":"10.1155","volume":"2012","author":[{"given":"S.","family":"Nobari","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering, McGill University, Montreal, QC, Canada H3A 2B4"},{"name":"Department of Cardiovascular Surgery, Montreal Heart Institute, Montreal, QC, Canada H1T 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