{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T11:19:13Z","timestamp":1720005553885},"reference-count":40,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To explore evidence for the traditional Tibetan medicine, Zhi Byed 11 (ZB11), for use as a uterotonic.<jats:italic>Methods<\/jats:italic>. The eleven ingredients in ZB11 were chemically analyzed by mass spectroscopy. A review was conducted of Western allopathic literature for scientific studies on ZB11\u2019s individual components. Literature from Tibetan and other traditional paradigms were reviewed.<jats:italic>Results<\/jats:italic>. Potential mechanisms of action for ZB11 as a uterotonic include laxative effects, a dose-dependant increase in smooth muscle tissue peristalsis that may also affect the uterus smooth muscle, and chemical components that are prostaglandin precursors and\/or increase prostaglandin synthesis. A recent RCT demonstrated comparable efficacy to misoprostol in reducing severe postpartum hemorrhage (PPH) (&gt;1000\u2009mL) and greater effect than placebo. Historical and anecdotal evidence for ZB11 and its ingredients for childbirth provide further support.<jats:italic>Discussion<\/jats:italic>. ZB11 and its ingredients are candidates for potentially effective uterotonics, especially in low-resource settings. Further research is warranted to understand the mechanisms of action and synergy between ingredients.<\/jats:p>","DOI":"10.1155\/2012\/794164","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T19:01:06Z","timestamp":1311274866000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["The Tibetan Uterotonic Zhi Byed 11: Mechanisms of Action, Efficacy, and Historical Use for Postpartum Hemorrhage"],"prefix":"10.1155","volume":"2012","author":[{"given":"Rebecca Lynn","family":"Coelius","sequence":"first","affiliation":[{"name":"School of Medicine, University of California, San Francisco, 50 Beale Street, Suite 1200, San Francisco, CA 94105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Stenson","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, David Geffen School of Medicine, Center for the Health Sciences, University of California, Los Angeles, 10,833 Le Conte Avenue, Los Angeles, CA 90095, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica L.","family":"Morris","sequence":"additional","affiliation":[{"name":"Safe Motherhood Program, University of California, San Francisco, 50 Beale Street, Suite 1200, San Francisco, CA 94105, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingji","family":"Cuomu","sequence":"additional","affiliation":[{"name":"The Institute for Social and Cultural Anthropology, University of Oxford, 386 London Road, Headington, Oxford OX3 8DW, UK"},{"name":"Tibetan Medical College, Lhasa, Tibet 850000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carrie","family":"Tudor","sequence":"additional","affiliation":[{"name":"School of Nursing, The Johns Hopkins University, 525 N. 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